. "Beta-lactamasa (\u03B2-lactamasa) \u00E9s una classe d'enzim produ\u00EFt per alguns bacteris i \u00E9s responsable de la seva resist\u00E8ncia als antibi\u00F2tics beta-lact\u00E0mics com penicil\u00B7lines, cefalosporines (s\u00F3n relativament resistents a les betalactamases), , i. Aquests antibi\u00F2tics tenen un element com\u00FA en la seva estructura molecular: un anell de quatre \u00E0toms, coneguts com a beta-lact\u00E0mics. L'enzim lactamasa trenca aquest anell obert, desactivant les propietats antibacterianes de la mol\u00E8cula.Els antibi\u00F2tics beta-lact\u00E0mics s'utilitzen normalment per tractar un ampli espectre de bacteris gram-positius i gram-negatius. Les beta-lactamases produ\u00EFdes per microorganismes gram-negatius solen ser secretades.Les beta-lactamases poden ser cl\u00EDnicament beneficioses quan s'administren per via oral per preservar la flora intestinal, durant l'administraci\u00F3 parenteral d'antibi\u00F2tics. \"Aix\u00F2 podria proporcionar una protecci\u00F3 contra una \u00E0mplia gamma de pat\u00F2gens nosocomials,\" per la Dra Usha Stiefel a la 47a confer\u00E8ncia anual de Interscience de Antimicrobial Agents and Chemotherapy. L'estructura d'una \u03B2-lactamasa de Streptomices est\u00E0 donada per 1BSG."@ca . . . . "\u0392-\u5185\u9170\u80FA\u9176"@zh . "B\u00EAta-lactamase"@fr . . "La betalactamasa (a veces usado con el guion: beta-lactamasa) es una enzima (EC 3.5.2.6) producida por algunas bacterias y es responsable de la resistencia de \u00E9stas ante la acci\u00F3n de antibi\u00F3ticos betalact\u00E1micos como las penicilinas, las cefalosporinas, monobactamicos y carbapen\u00E9micos (carbapenemasas). Todos estos antibi\u00F3ticos tienen un elemento en com\u00FAn dentro de su estructura molecular denominado anillo betalact\u00E1mico, un anillo qu\u00EDmico de cuatro \u00E1tomos. Las lactamasas rompen el anillo, desactivando las propiedades antimicrobianas de la mol\u00E9cula. Las betalactamasas por lo general son producidas por bacterias Gram negativas en forma secretada. Por lo general, las cepas resistentes a la penicilina se relaciona directamente con el porcentaje de cepas productoras de betalactamasa.\u200B"@es . . . . . . "Beta-laktam\u00E1zy jsou enzymy (\u010D\u00EDslo EC 3.5.2.6) produkovan\u00E9 n\u011Bkter\u00FDmi bakteriemi a zodpov\u011Bdn\u00E9 za jejich rezistenci na beta-laktamov\u00E1 antibiotika, nap\u0159\u00EDklad peniciliny, a karbapenemy. Cefalosporiny jsou na beta-laktam\u00E1zu relativn\u011B rezistentn\u00ED. Tato antibiotika maj\u00ED ve sv\u00E9 molekul\u00E1rn\u00ED struktu\u0159e spole\u010Dn\u00FD element: \u010Dty\u0159atomov\u00FD kruh zn\u00E1m\u00FD jako beta-laktam. Laktam\u00E1zov\u00FD enzym tento kruh otev\u00EDr\u00E1 a deaktivuje antibakteri\u00E1ln\u00ED vlastnosti molekuly."@cs . . ", , , , , , , , , , ,"@en . . . . . . . . . "\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\uFF08\u30D9\u30FC\u30BF\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3001\u03B2-lactamase\uFF09\u3068\u306F\u03B2\u2010\u30E9\u30AF\u30BF\u30E0\u7CFB\u6297\u751F\u7269\u8CEA\u3092\u52A0\u6C34\u5206\u89E3\u3059\u308B\u9175\u7D20\u3067\u3042\u308B\u3002\u30DA\u30CB\u30B7\u30EA\u30F3/\u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30F3\u30A2\u30DF\u30C9-\u03B2-\u30E9\u30AF\u30BF\u30E0\u30D2\u30C9\u30ED\u30E9\u30FC\u30BC (penicillin\uFF0Fcepharosporin amido-\u03B2-lactam hydrolase)\u3068\u3082\u547C\u3070\u308C\u308B\u3002EC3.5.2.6\u306B\u5206\u985E\u3055\u308C\u308B\u9175\u7D20\u3067\u3042\u308B\u3002 \u5E7E\u3064\u304B\u306E\u7A2E\u985E\u306E\u30B0\u30E9\u30E0\u9670\u6027\u83CC\u304C\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3092\u7523\u751F\u3059\u308B\u3053\u3068\u3067\u03B2-\u30E9\u30AF\u30BF\u30E0\u306B\u5BFE\u3057\u3066\u8010\u6027\u3092\u793A\u3059\u3053\u3068\u304C\u77E5\u3089\u308C\u3066\u3044\u308B\u3002\u306A\u304A\u3001\u03B2-\u30E9\u30AF\u30BF\u30E0\u8010\u6027\u306F\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306E\u307F\u304C\u539F\u56E0\u3067\u306F\u306A\u304FMRSA\u306E\u3088\u3046\u306B\u30DA\u30CB\u30B7\u30EA\u30F3\u7D50\u5408\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u57FA\u8CEA\u7279\u7570\u6027\u304C\u5909\u5316\u3057\u3066\u3082\u73FE\u308C\u308B\u3002 \u73FE\u5728\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306F\u57FA\u8CEA\u7279\u7570\u6027\u306E\u9055\u3044\u306B\u3088\u308A \n* \u30DA\u30CB\u30B7\u30EA\u30CA\u30FC\u30BC (\u30AF\u30E9\u30B9A \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC) \n* \u30E1\u30BF\u30ED-\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC (\u30AF\u30E9\u30B9B \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3001\u4E9C\u925B-\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3001\u30AB\u30EB\u30D0\u30DA\u30CD\u30DE\u30FC\u30BC) \n* \u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30CA\u30FC\u30BC (\u30AF\u30E9\u30B9C \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC) \n* \u30AA\u30AD\u30B5\u30B7\u30EA\u30CA\u30FC\u30BC (\u30AF\u30E9\u30B9D \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC) \u304C\u5B58\u5728\u3059\u308B\u3002 \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306E\u907A\u4F1D\u5B50\u306F\u3001\u7D30\u83CC\u306E\u67D3\u8272\u4F53\u4E0A\u3042\u308B\u3044\u306F\u30D7\u30E9\u30B9\u30DF\u30C9\u4E0A\u306B\u5B58\u5728\u3059\u308B\u3002\u7279\u306B\u4F1D\u9054\u6027\u85AC\u5264\u8010\u6027\u30D7\u30E9\u30B9\u30DF\u30C9 (drug resistance plasmid\uFF09\u306B\u5B58\u5728\u3059\u308B\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u907A\u4F1D\u5B50\u306F\u83CC\u7A2E\u7279\u7570\u6027\u3082\u5C11\u306A\u304F\u591A\u5264\u8010\u6027\u83CC\u306E\u767A\u751F\u306B\u3082\u95A2\u4E0E\u3057\u3066\u3044\u308B\u3068\u8003\u3048\u3089\u308C\u308B\u3002"@ja . . "Beta-lattamasi"@it . . . "Metallo-beta-lactamase L1 homotetramer, Stenotrophomonas"@en . . . . . . . . "Le \u03B2-lattamasi sono enzimi (numero EC 3.5.2.6) prodotti da alcuni batteri e responsabili della loro resistenza agli antibiotici \u03B2-lattamici come le penicilline, le e le cefalosporine (i carbapenemi sono relativamente resistenti alle \u03B2-lattamasi). Questi enzimi inattivano l\u2019attivit\u00E0 di questi antibiotici idrolizzando la struttura comune a tutti questi: l\u2019anello \u03B2-lattamico. Le \u03B2-lattamasi sono capaci di rompere questa struttura rendendo il principio attivo poco funzionale e, di conseguenza, incapace di uccidere il batterio. Il meccanismo di idrolizzazione avviene in due fasi: 1. \n* acilazione (che avviene attraverso l'attacco covalente al \u03B2-lattame ad opera della serina70) 2. \n* deacilazione Acquisendo la capacit\u00E0 di produrre questi enzimi, i batteri diventano resistenti ai farmaci e conoscerne i meccanismi fornisce gli strumenti per lo sviluppo di inibitori e nuovi antibiotici. Purtroppo, il fenomeno dell'antibiotico-resistenza \u00E8 notevolmente aumentato negli ultimi anni, soprattutto per colpa dell'abuso e del cattivo uso che ne viene fatto. Pertanto questi farmaci rischiano sempre pi\u00F9 di diventare inutili a causa del continuo sviluppo di ceppi batterici resistenti. I batteri in grado di produrre questo tipo di enzimi sono quelli che posseggono i geni della resistenza a questi antibiotici, questi possono essere acquisiti in due modi: \n* trasferimento genico verticale: questo tipo di meccanismo prevede mutazioni spontanee, per le quali il batterio sviluppa questa linea difensiva, che vengono selezionate nel corso dell\u2019evoluzione. Tuttavia questo avviene in maniera molto rara. \n* trasferimento genico orizzontale: meccanismo per il quale il gene della resistenza viene acquisito da altri batteri. Questo pu\u00F2 avvenire in tre modi: \n* congiunzione: un batterio che possiede un plasmide con il gene della resistenza agli antibiotici, si attacca ad un altro battere, facendo s\u00EC che il plasmide si replichi nel citoplasma di quest\u2019ultimo che acquista il gene. \n* trasduzione: il batterio assume il gene per la resistenza attraverso un fago da cui viene attaccato e che aveva precedentemente attaccato un batterio con quel gene e dal quale lo aveva assimilato replicando il proprio DNA nel suo. \n* trasformazione: il gene viene appreso attraverso l\u2019assorbimento da parte di un batterio del materiale genetico di un altro che lo possedeva nel momento in cui questo muore e libera il proprio materiale genetico."@it . . "Betalactamases (\u03B2-lactamases) s\u00E3o enzimas produzidas por algumas bact\u00E9rias e s\u00E3o respons\u00E1veis por sua resist\u00EAncia a antibi\u00F3ticos beta-lact\u00E2micos como as penicilinas, cefalosporinas, cefamicinas e carbapenemas. Estes antibi\u00F3ticos t\u00EAm como elemento comum em suas estruturas moleculares um anel de quatro \u00E1tomos conhecido como beta-lactama. A enzima lactamase quebra este anel, desativando as propriedades antibacterianas da mol\u00E9cula. Antibi\u00F3ticos beta-lact\u00E2micos s\u00E3o usados para tratar um largo espectro de bact\u00E9rias Gram-positivas e Gram-negativas. As beta-lactamases produzidas por organismos Gram-positivos s\u00E3o usualmente secretadas."@pt . . "\uBCA0\uD0C0-\uB77D\uD0C0\uBA54\uC774\uC2A4"@ko . . "1120305486"^^ . . . "56601"^^ . "\u0411\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u0438 (\u03B2-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u0438) \u2014 \u0446\u0435 \u0433\u0440\u0443\u043F\u0430 \u0431\u0430\u043A\u0442\u0435\u0440\u0456\u0430\u043B\u044C\u043D\u0438\u0445 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0456\u0432, \u044F\u043A\u0456 \u0437\u0434\u0430\u0442\u043D\u0456 \u0440\u043E\u0437\u0440\u0438\u0432\u0430\u0442\u0438 \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u043D\u0435 \u043A\u0456\u043B\u044C\u0446\u0435 \u0434\u0435\u044F\u043A\u0438\u0445 \u0430\u043D\u0442\u0438\u0431\u0456\u043E\u0442\u0438\u043A\u0456\u0432 (\u043F\u0435\u043D\u0456\u0446\u0438\u043B\u0456\u043D\u0456\u0432, \u0446\u0435\u0444\u0430\u043B\u043E\u0441\u043F\u043E\u0440\u0438\u043D\u0456\u0432, \u043A\u0430\u0440\u0431\u0430\u043F\u0435\u043D\u0435\u043C\u0456\u0432 \u0442\u0430 \u043C\u043E\u043D\u043E\u0431\u0430\u043A\u0442\u0430\u043C\u0456\u0432), \u0449\u043E \u043D\u0430\u043B\u0435\u0436\u0430\u0442\u044C \u0434\u043E \u043A\u043B\u0430\u0441\u0443 \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0456\u0432."@uk . "\u0392-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC"@ja . . . . . "\u03B2-\u5185\u9170\u80FA\u9176\uFF08\u03B2-lactamases\uFF09\uFF0C\u53C8\u7A31\u70BA\u76E4\u5C3C\u897F\u6797\u9176\uFF08Penicillinase\uFF09\u3001\u982D\u5B62\u83CC\u7D20\u9176\uFF08Cephalosporinase\uFF09\uFF0C\u662F\u4E00\u985E\u7531\u67D0\u4E9B\u7EC6\u83CC\u751F\u6210\u6765\u63D0\u4F9B\u591A\u91CD\u6297\u85E5\u6027\uFF0C\u5BF9\u6297\u03B2-\u5185\u9170\u80FA\u7C7B\u6297\u751F\u7D20\uFF08\u6BD4\u5982\u9752\u9709\u7D20\u3001\u5934\u5B62\u83CC\u7D20\u3001\u3001\u78B3\u9752\u9709\u70EF\u7B49\uFF09\u7684\u9176(EC 3.5.2.6)\u3002 \u03B2-\u5185\u9170\u80FA\u7C7B\u6297\u751F\u7D20\u662F\u73B0\u6709\u7684\u6297\u751F\u7D20\u4E2D\u4F7F\u7528\u6700\u5E7F\u6CDB\u7684\u4E00\u7C7B\uFF0C\u901A\u5E38\u517C\u7528\u65BC\u5C0D\u6297\u9769\u862D\u6C0F\u967D\u6027\u83CC\u8207\u9769\u862D\u6C0F\u9670\u6027\u83CC\u3002\u800C\u03B2-\u5185\u9170\u80FA\u9176\u901A\u8FC7\u6253\u7834\u6297\u751F\u7D20\u7684\u5206\u5B50\u7ED3\u6784\u6765\u63D0\u4F9B\u6297\u836F\u6027\u3002\u8FD9\u4E9B\u6297\u751F\u7D20\u7684\u5206\u5B50\u7ED3\u6784\u6709\u4E00\u4E2A\u5171\u540C\u70B9\uFF1A\u79F0\u4E3A\u03B2-\u5185\u9170\u80FA\u7684\u56DB\u5143\u73AF\u6838\u5FC3\u3002\u03B2-\u5185\u9170\u80FA\u9176\u5229\u7528\u6C34\u89E3\u6253\u7834\u4E86\u03B2-\u5185\u9170\u80FA\u56DB\u5143\u73AF\u4F7F\u6297\u751F\u7D20\u5206\u5B50\u5931\u53BB\u836F\u7406\u4F5C\u7528\u3002 \u03B2-\u5185\u9170\u80FA\u9176\u901A\u5E38\u7531\u9769\u5170\u6C0F\u9634\u6027\u83CC\u751F\u6210\uFF0C\u7279\u522B\u662F\u5728\u6709\u6297\u751F\u7D20\u7684\u73AF\u5883\u4E2D\u3002"@zh . . . . . . . "\u0627\u0644\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632: \u0647\u064A \u0627\u0646\u0632\u064A\u0645\u0627\u062A \u062A\u0646\u062A\u062C \u0628\u0648\u0627\u0633\u0637\u0629 \u0628\u0639\u0636 \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u0627 \u0623\u0648 \u0627\u0644\u062C\u0631\u0627\u062B\u064A\u0645 \u0633\u0644\u0628\u064A\u0627\u062A \u063A\u0631\u0627\u0645 \u0648\u0625\u064A\u062C\u0627\u0628\u064A\u0627\u062A \u063A\u0631\u0627\u0645 \u0648\u0647\u064A \u0627\u0644\u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0635\u0641 \u0648\u0627\u0633\u0639 \u0645\u0646 \u0627\u0644\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u062D\u064A\u0648\u064A\u0629 \u0627\u0644\u0645\u062A\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u060C \u0648\u0627\u0644\u062A\u064A \u0645\u0646\u0647\u0627 \u0627\u0644\u0628\u0646\u0633\u0644\u064A\u0646. \u0648\u062A\u0648\u062C\u062F \u0645\u062C\u0645\u0648\u0639\u0627\u062A \u0648\u0635\u0646\u0648\u0641 \u0639\u062F\u064A\u062F\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0632\u064A\u0645\u0627\u062A \u0627\u0644\u062A\u064A \u062A\u0642\u0627\u0648\u0645 \u0627\u0644\u0645\u0636\u0627\u062F \u0627\u0644\u062D\u064A\u0648\u064A.\u0639\u0644\u0649 \u0633\u0628\u064A\u0644 \u0627\u0644\u0645\u062B\u0627\u0644: \u0635\u0641\u0648\u0641 \u0645\u062A\u0639\u062F\u062F\u0629 \u0645\u0646 \u0623\u0646\u0632\u064A\u0645\u0627\u062A \u00AB\u0633. \u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632\u00BB \u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0633\u064A\u0641\u0627\u0644\u0648\u0633\u0628\u0648\u0631\u064A\u0646 \u0648\u0628\u0639\u0636 \u0635\u0641\u0648\u0641 \u00AB\u0622. \u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632\u00BB \u064A\u0639\u0637\u064A \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u00AB\u0644\u0644\u0623\u0648\u0643\u0633\u064A\u0645\u064A\u0646\u0648 \u0633\u064A\u0641\u0627\u0644\u0648\u0633\u0628\u0648\u0631\u064A\u0646\u0627\u062A\u00BB \u060C \u00AB\u0633\u064A\u0641\u0627\u0645\u064A\u0633\u064A\u0646\u0627\u062A\u00BB \u0648\u0643\u0627\u0631\u0628\u0627\u0628\u064A\u0646\u064A\u0645\u0627\u062A.\u062D\u062F\u064A\u062B\u0627\u064B \u062A\u0645 \u062A\u062D\u062F\u064A\u062F \u0628\u0646\u064A\u062A\u064A\u0646 \u0645\u062E\u062A\u0644\u0641\u064A\u0646 \u0644\u0623\u0646\u0632\u064A\u0645 \u0627\u0644\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632."@ar . . . . . . . "\u03B2-Laktamazy \u2013 bakteryjne enzymy rozrywaj\u0105ce (dok\u0142adnie hydrolizuj\u0105ce) wi\u0105zanie \u03B2-laktamowe w cz\u0105steczce antybiotyku \u03B2-laktamowego. Ich obecno\u015B\u0107 w kom\u00F3rkach bakteryjnych jest \u017Ar\u00F3d\u0142em oporno\u015Bci bakterii na ten rodzaj antybiotyk\u00F3w. \u03B2-laktamazy s\u0105 wydzielane przez bakterie Gram-dodatnie na zewn\u0105trz kom\u00F3rki, a przez bakterie Gram-ujemne do przestrzeni periplazmatycznej."@pl . "PS00146"@en . . . . . . . "Beta-lactamasa (\u03B2-lactamasa) \u00E9s una classe d'enzim produ\u00EFt per alguns bacteris i \u00E9s responsable de la seva resist\u00E8ncia als antibi\u00F2tics beta-lact\u00E0mics com penicil\u00B7lines, cefalosporines (s\u00F3n relativament resistents a les betalactamases), , i. Aquests antibi\u00F2tics tenen un element com\u00FA en la seva estructura molecular: un anell de quatre \u00E0toms, coneguts com a beta-lact\u00E0mics. L'enzim lactamasa trenca aquest anell obert, desactivant les propietats antibacterianes de la mol\u00E8cula.Els antibi\u00F2tics beta-lact\u00E0mics s'utilitzen normalment per tractar un ampli espectre de bacteris gram-positius i gram-negatius. Les beta-lactamases produ\u00EFdes per microorganismes gram-negatius solen ser secretades.Les beta-lactamases poden ser cl\u00EDnicament beneficioses quan s'administren per via oral per preservar la flor"@ca . . . "Serine beta-lactamase"@en . . "IPR001466"@en . . . . . . . . "\u03B2-Lactamasen sind Enzyme, die von zahlreichen Bakterien gebildet werden. Sie hydrolysieren einen gemeinsamen strukturellen Bestandteil der \u03B2-Lactam-Antibiotika, den \u03B2-Lactam-Ring, und verhindern dadurch die Wirkung dieser Arzneistoffe. Je nach Ansatzpunkt unterscheidet man zwischen Penicillinasen, Cephalosporinasen und Carbapenemasen. \u03B2-Lactamasen spielen daher eine wichtige Rolle bei der gef\u00FCrchteten Antibiotika-Resistenz von Bakterien. Die genetische Information zur Synthese der \u03B2-Lactamasen wird sowohl chromosomal als auch plasmid\u00E4r vererbt. Hemmstoffe der \u03B2-Lactamasen sind die \u03B2-Lactamase-Inhibitoren."@de . "\uBCA0\uD0C0-\uB77D\uD0C0\uBA54\uC774\uC2A4(\uC601\uC5B4: \u03B2-lactamase) \uB610\uB294 \uBCA0\uD0C0-\uB77D\uD0D0 \uAC00\uC218\uBD84\uD574\uD6A8\uC18C\uB294 \uBCA0\uD0C0-\uB77D\uD0D0\uACC4\uC5F4 \uD56D\uC0DD\uC81C\uC5D0\uAC8C \uAC10\uC218\uC131\uC774 \uC788\uB294 \uC138\uADE0\uB4E4\uC758 \uB300\uC751(\uBC29\uC5B4\uCC45)\uC73C\uB85C \uC0DD\uC131\uB418\uB294 \uD6A8\uC18C\uC758 \uC77C\uC885\uC774\uB2E4. \uBCA0\uD0C0-\uB77D\uD0C0\uBA54\uC774\uC2A4\uB294 \uBCA0\uD0C0-\uB77D\uD0D0\uACC4\uC5F4 \uD56D\uC0DD\uC81C\uC758 \uBCA0\uD0C0-\uB77D\uD0D0 \uACE0\uB9AC\uB97C \uB04A\uC5B4\uB728\uB824 \uD56D\uADE0\uD6A8\uACFC\uB97C \uC5B5\uC81C\uD55C\uB2E4."@ko . . . "\u0411\u0435\u0301\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0301\u0437\u044B (\u03B2-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u044B) \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0430\u043B\u044C\u043D\u044B\u0445 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u043E\u0432, \u043D\u0430\u043F\u0440\u0430\u0432\u043B\u0435\u043D\u043D\u044B\u0445 \u043D\u0430 \u0431\u043E\u0440\u044C\u0431\u0443 \u0441 \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u043D\u044B\u043C\u0438 \u0430\u043D\u0442\u0438\u0431\u0438\u043E\u0442\u0438\u043A\u0430\u043C\u0438 (\u043F\u0435\u043D\u0438\u0446\u0438\u043B\u043B\u0438\u043D\u044B, \u0446\u0435\u0444\u0430\u043B\u043E\u0441\u043F\u043E\u0440\u0438\u043D\u044B \u0438 \u0434\u0440.), \u043D\u0430\u0438\u0431\u043E\u043B\u0435\u0435 \u0448\u0438\u0440\u043E\u043A\u043E \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u0435\u043C\u044B\u043C \u043A\u043B\u0430\u0441\u0441\u043E\u043C \u0432\u0435\u0449\u0435\u0441\u0442\u0432 \u0434\u043B\u044F \u0430\u043D\u0442\u0438\u043C\u0438\u043A\u0440\u043E\u0431\u043D\u043E\u0439 \u0445\u0438\u043C\u0438\u043E\u0442\u0435\u0440\u0430\u043F\u0438\u0438. \u0414\u0430\u043D\u043D\u044B\u0435 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u044B \u043E\u0442\u0432\u0435\u0447\u0430\u044E\u0442 \u0437\u0430 \u043E\u0431\u0440\u0430\u0437\u043E\u0432\u0430\u043D\u0438\u0435 \u0431\u043E\u043B\u0435\u0435 \u0440\u0430\u0441\u043F\u0440\u043E\u0441\u0442\u0440\u0430\u043D\u0451\u043D\u043D\u043E\u0439 \u0443\u0441\u0442\u043E\u0439\u0447\u0438\u0432\u043E\u0441\u0442\u0438 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0439 \u043A \u043D\u0430\u0437\u0432\u0430\u043D\u043D\u044B\u043C \u0430\u043D\u0442\u0438\u0431\u0438\u043E\u0442\u0438\u043A\u0430\u043C. \u0412\u0442\u043E\u0440\u044B\u043C \u043F\u0443\u0442\u0451\u043C \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044F \u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043D\u0442\u043D\u043E\u0441\u0442\u0438 \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0438\u0437\u043C\u0435\u043D\u0435\u043D\u0438\u0435 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u044B , \u0442\u043E \u0435\u0441\u0442\u044C \u0442\u0435\u0445 \u0431\u0435\u043B\u043A\u043E\u0432, \u043D\u0430 \u043A\u043E\u0442\u043E\u0440\u044B\u0435 \u043D\u0430\u0446\u0435\u043B\u0435\u043D\u044B \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u043D\u044B\u0435 \u0430\u043D\u0442\u0438\u0431\u0438\u043E\u0442\u0438\u043A\u0438 (\u0441\u043C. , \u041C\u0420\u0417\u0421). \u0414\u043B\u044F \u0431\u043E\u0440\u044C\u0431\u044B \u0441 \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u0430\u043C\u0438 \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u0443\u044E\u0442\u0441\u044F \u0438\u043D\u0433\u0438\u0431\u0438\u0442\u043E\u0440\u044B \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437, \u043F\u0440\u0438\u043D\u0438\u043C\u0430\u0435\u043C\u044B\u0435 \u0432\u043C\u0435\u0441\u0442\u0435 \u0441 \u0430\u043D\u0442\u0438\u0431\u0438\u043E\u0442\u0438\u043A\u043E\u043C."@ru . . . . . . . . . . . . . . . . . "PF00144"@en . . "Le \u03B2-lattamasi sono enzimi (numero EC 3.5.2.6) prodotti da alcuni batteri e responsabili della loro resistenza agli antibiotici \u03B2-lattamici come le penicilline, le e le cefalosporine (i carbapenemi sono relativamente resistenti alle \u03B2-lattamasi). Questi enzimi inattivano l\u2019attivit\u00E0 di questi antibiotici idrolizzando la struttura comune a tutti questi: l\u2019anello \u03B2-lattamico. Le \u03B2-lattamasi sono capaci di rompere questa struttura rendendo il principio attivo poco funzionale e, di conseguenza, incapace di uccidere il batterio. Il meccanismo di idrolizzazione avviene in due fasi:"@it . . . "\uBCA0\uD0C0-\uB77D\uD0C0\uBA54\uC774\uC2A4(\uC601\uC5B4: \u03B2-lactamase) \uB610\uB294 \uBCA0\uD0C0-\uB77D\uD0D0 \uAC00\uC218\uBD84\uD574\uD6A8\uC18C\uB294 \uBCA0\uD0C0-\uB77D\uD0D0\uACC4\uC5F4 \uD56D\uC0DD\uC81C\uC5D0\uAC8C \uAC10\uC218\uC131\uC774 \uC788\uB294 \uC138\uADE0\uB4E4\uC758 \uB300\uC751(\uBC29\uC5B4\uCC45)\uC73C\uB85C \uC0DD\uC131\uB418\uB294 \uD6A8\uC18C\uC758 \uC77C\uC885\uC774\uB2E4. \uBCA0\uD0C0-\uB77D\uD0C0\uBA54\uC774\uC2A4\uB294 \uBCA0\uD0C0-\uB77D\uD0D0\uACC4\uC5F4 \uD56D\uC0DD\uC81C\uC758 \uBCA0\uD0C0-\uB77D\uD0D0 \uACE0\uB9AC\uB97C \uB04A\uC5B4\uB728\uB824 \uD56D\uADE0\uD6A8\uACFC\uB97C \uC5B5\uC81C\uD55C\uB2E4."@ko . . . . . . . . "Metallo-beta-lactamase"@en . . . . . . . . "\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632"@ar . . . . . "September 2021"@en . . "confusing mix of structural and functional classifications; need explanatory paragraph on what these classes are"@en . . . . . . . . . "4609"^^ . . . . . . . . . . . "3.5"^^ . . "9073"^^ . . . . . "51083"^^ . "\u0411\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u0438 (\u03B2-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u0438) \u2014 \u0446\u0435 \u0433\u0440\u0443\u043F\u0430 \u0431\u0430\u043A\u0442\u0435\u0440\u0456\u0430\u043B\u044C\u043D\u0438\u0445 \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0456\u0432, \u044F\u043A\u0456 \u0437\u0434\u0430\u0442\u043D\u0456 \u0440\u043E\u0437\u0440\u0438\u0432\u0430\u0442\u0438 \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u043D\u0435 \u043A\u0456\u043B\u044C\u0446\u0435 \u0434\u0435\u044F\u043A\u0438\u0445 \u0430\u043D\u0442\u0438\u0431\u0456\u043E\u0442\u0438\u043A\u0456\u0432 (\u043F\u0435\u043D\u0456\u0446\u0438\u043B\u0456\u043D\u0456\u0432, \u0446\u0435\u0444\u0430\u043B\u043E\u0441\u043F\u043E\u0440\u0438\u043D\u0456\u0432, \u043A\u0430\u0440\u0431\u0430\u043F\u0435\u043D\u0435\u043C\u0456\u0432 \u0442\u0430 \u043C\u043E\u043D\u043E\u0431\u0430\u043A\u0442\u0430\u043C\u0456\u0432), \u0449\u043E \u043D\u0430\u043B\u0435\u0436\u0430\u0442\u044C \u0434\u043E \u043A\u043B\u0430\u0441\u0443 \u0431\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0456\u0432."@uk . . . "\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\uFF08\u30D9\u30FC\u30BF\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3001\u03B2-lactamase\uFF09\u3068\u306F\u03B2\u2010\u30E9\u30AF\u30BF\u30E0\u7CFB\u6297\u751F\u7269\u8CEA\u3092\u52A0\u6C34\u5206\u89E3\u3059\u308B\u9175\u7D20\u3067\u3042\u308B\u3002\u30DA\u30CB\u30B7\u30EA\u30F3/\u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30F3\u30A2\u30DF\u30C9-\u03B2-\u30E9\u30AF\u30BF\u30E0\u30D2\u30C9\u30ED\u30E9\u30FC\u30BC (penicillin\uFF0Fcepharosporin amido-\u03B2-lactam hydrolase)\u3068\u3082\u547C\u3070\u308C\u308B\u3002EC3.5.2.6\u306B\u5206\u985E\u3055\u308C\u308B\u9175\u7D20\u3067\u3042\u308B\u3002 \u5E7E\u3064\u304B\u306E\u7A2E\u985E\u306E\u30B0\u30E9\u30E0\u9670\u6027\u83CC\u304C\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3092\u7523\u751F\u3059\u308B\u3053\u3068\u3067\u03B2-\u30E9\u30AF\u30BF\u30E0\u306B\u5BFE\u3057\u3066\u8010\u6027\u3092\u793A\u3059\u3053\u3068\u304C\u77E5\u3089\u308C\u3066\u3044\u308B\u3002\u306A\u304A\u3001\u03B2-\u30E9\u30AF\u30BF\u30E0\u8010\u6027\u306F\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306E\u307F\u304C\u539F\u56E0\u3067\u306F\u306A\u304FMRSA\u306E\u3088\u3046\u306B\u30DA\u30CB\u30B7\u30EA\u30F3\u7D50\u5408\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E\u57FA\u8CEA\u7279\u7570\u6027\u304C\u5909\u5316\u3057\u3066\u3082\u73FE\u308C\u308B\u3002 \u73FE\u5728\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306F\u57FA\u8CEA\u7279\u7570\u6027\u306E\u9055\u3044\u306B\u3088\u308A \n* \u30DA\u30CB\u30B7\u30EA\u30CA\u30FC\u30BC (\u30AF\u30E9\u30B9A \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC) \n* \u30E1\u30BF\u30ED-\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC (\u30AF\u30E9\u30B9B \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3001\u4E9C\u925B-\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u3001\u30AB\u30EB\u30D0\u30DA\u30CD\u30DE\u30FC\u30BC) \n* \u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30CA\u30FC\u30BC (\u30AF\u30E9\u30B9C \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC) \n* \u30AA\u30AD\u30B5\u30B7\u30EA\u30CA\u30FC\u30BC (\u30AF\u30E9\u30B9D \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC) \u304C\u5B58\u5728\u3059\u308B\u3002 \u3053\u308C\u30894\u7A2E\u306E\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306E\u3046\u3061\u3001\u30AF\u30E9\u30B9B \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306F\u6D3B\u6027\u4E2D\u5FC3\u306B\u4E9C\u925B\u3092\u6301\u3064\u304C\u3001\u4ED6\u306F\u30BB\u30EA\u30F3\u6B8B\u57FA\u3092\u6301\u3064\u3002\u30DA\u30CB\u30B7\u30EA\u30CA\u30FC\u30BC\u306F\u30DA\u30CB\u30B7\u30EA\u30F3\u7CFB\u6297\u751F\u7269\u8CEA\u3068\u7B2C\u4E8C\u4E16\u4EE3\u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30F3\u3092\u5206\u89E3\u3059\u308B\u306E\u306B\u5BFE\u3057\u3066\u3001\u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30CA\u30FC\u30BC\u306F\u4E3B\u306B\u30BB\u30D5\u30A1\u30ED\u30B9\u30DD\u30EA\u30F3\u3092\u5206\u89E3\u3059\u308B\u3002\u30AA\u30AD\u30B5\u30B7\u30EA\u30CA\u30FC\u30BC\u306F\u30AA\u30AD\u30B5\u30B7\u30EA\u30F3\u3092\u3082\u5206\u89E3\u3059\u308B\u30DA\u30CB\u30B7\u30EA\u30CA\u30FC\u30BC\u3067\u3042\u308A\u3001\u30E1\u30BF\u30ED-\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306F\u30AB\u30EB\u30D0\u30DA\u30CD\u30E0\u7CFB\u6297\u751F\u7269\u8CEA\u3092\u5206\u89E3\u3059\u308B\u70B9\u306B\u7279\u5FB4\u304C\u3042\u308B\u3002 \u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u306E\u907A\u4F1D\u5B50\u306F\u3001\u7D30\u83CC\u306E\u67D3\u8272\u4F53\u4E0A\u3042\u308B\u3044\u306F\u30D7\u30E9\u30B9\u30DF\u30C9\u4E0A\u306B\u5B58\u5728\u3059\u308B\u3002\u7279\u306B\u4F1D\u9054\u6027\u85AC\u5264\u8010\u6027\u30D7\u30E9\u30B9\u30DF\u30C9 (drug resistance plasmid\uFF09\u306B\u5B58\u5728\u3059\u308B\u03B2-\u30E9\u30AF\u30BF\u30DE\u30FC\u30BC\u907A\u4F1D\u5B50\u306F\u83CC\u7A2E\u7279\u7570\u6027\u3082\u5C11\u306A\u304F\u591A\u5264\u8010\u6027\u83CC\u306E\u767A\u751F\u306B\u3082\u95A2\u4E0E\u3057\u3066\u3044\u308B\u3068\u8003\u3048\u3089\u308C\u308B\u3002"@ja . . . . . . . . "Beta-lactamases, (\u03B2-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (\u03B2-lactam) ring. Through hydrolysis, the enzyme lactamase breaks the \u03B2-lactam ring open, deactivating the molecule's antibacterial properties."@en . "\u0392-Laktamazy"@pl . . "\u03B2-lactamase domain"@en . "Action of \u03B2-lactamase and decarboxylation of the intermediate"@en . . . . . . "Beta-laktam\u00E1zy jsou enzymy (\u010D\u00EDslo EC 3.5.2.6) produkovan\u00E9 n\u011Bkter\u00FDmi bakteriemi a zodpov\u011Bdn\u00E9 za jejich rezistenci na beta-laktamov\u00E1 antibiotika, nap\u0159\u00EDklad peniciliny, a karbapenemy. Cefalosporiny jsou na beta-laktam\u00E1zu relativn\u011B rezistentn\u00ED. Tato antibiotika maj\u00ED ve sv\u00E9 molekul\u00E1rn\u00ED struktu\u0159e spole\u010Dn\u00FD element: \u010Dty\u0159atomov\u00FD kruh zn\u00E1m\u00FD jako beta-laktam. Laktam\u00E1zov\u00FD enzym tento kruh otev\u00EDr\u00E1 a deaktivuje antibakteri\u00E1ln\u00ED vlastnosti molekuly. Beta-laktamov\u00E1 antibiotika se typicky pou\u017E\u00EDvaj\u00ED k likvidaci \u0161irok\u00E9ho spektra grampozitivn\u00EDch a gramnegativn\u00EDch bakteri\u00ED. Beta-laktam\u00E1zy jsou obvykle uvol\u0148ov\u00E1ny gramnegativn\u00EDmi mikroby."@cs . . . "\u03B2-lactamase domain" . "La betalactamasa (a veces usado con el guion: beta-lactamasa) es una enzima (EC 3.5.2.6) producida por algunas bacterias y es responsable de la resistencia de \u00E9stas ante la acci\u00F3n de antibi\u00F3ticos betalact\u00E1micos como las penicilinas, las cefalosporinas, monobactamicos y carbapen\u00E9micos (carbapenemasas). Todos estos antibi\u00F3ticos tienen un elemento en com\u00FAn dentro de su estructura molecular denominado anillo betalact\u00E1mico, un anillo qu\u00EDmico de cuatro \u00E1tomos. Las lactamasas rompen el anillo, desactivando las propiedades antimicrobianas de la mol\u00E9cula. Las betalactamasas por lo general son producidas por bacterias Gram negativas en forma secretada. Por lo general, las cepas resistentes a la penicilina se relaciona directamente con el porcentaje de cepas productoras de betalactamasa.\u200B Es el mecanismo de resistencia a los \u03B2-lact\u00E1micos m\u00E1s importante en las enterobacterias y otros bacilos gramnegativos. Las \u03B2-lactamasas pueden ser cromos\u00F3micas o plasm\u00EDdicas.\u200B"@es . "8800"^^ . "\u03B2-Laktamazy \u2013 bakteryjne enzymy rozrywaj\u0105ce (dok\u0142adnie hydrolizuj\u0105ce) wi\u0105zanie \u03B2-laktamowe w cz\u0105steczce antybiotyku \u03B2-laktamowego. Ich obecno\u015B\u0107 w kom\u00F3rkach bakteryjnych jest \u017Ar\u00F3d\u0142em oporno\u015Bci bakterii na ten rodzaj antybiotyk\u00F3w. \u03B2-Laktamazy maj\u0105 budow\u0119 zbli\u017Con\u0105 do \u2013 bakteryjnych enzym\u00F3w uczestnicz\u0105cych w budowie \u015Bciany kom\u00F3rkowej, odpowiedzialnych za tworzenie mostk\u00F3w \u0142\u0105cz\u0105cych podjednostki peptydoglikanu (mureiny) w integraln\u0105 ca\u0142o\u015B\u0107. Transpeptydazy s\u0105 jednocze\u015Bnie bia\u0142kami, z kt\u00F3rymi w normalnej kom\u00F3rce bakteryjnej \u0142\u0105cz\u0105 si\u0119 antybiotyki \u03B2-laktamowe, aby je zablokowa\u0107 (transpeptydazy s\u0105 punktem uchwytu \u03B2-laktam\u00F3w \u2013 bia\u0142kami PBP). Ze wzgl\u0119du na to podobie\u0144stwo budowy \u03B2-laktamazy mog\u0105 \u0142atwo wi\u0105za\u0107 si\u0119 z cz\u0105steczkami antybiotyku i dezaktywowa\u0107 je (uniemo\u017Cliwiaj\u0105c im blokowanie transpeptydaz). \u03B2-laktamazy s\u0105 wydzielane przez bakterie Gram-dodatnie na zewn\u0105trz kom\u00F3rki, a przez bakterie Gram-ujemne do przestrzeni periplazmatycznej."@pl . . . . "IPR001279"@en . "3"^^ . . . . . . . . "Betalactamases (\u03B2-lactamases) s\u00E3o enzimas produzidas por algumas bact\u00E9rias e s\u00E3o respons\u00E1veis por sua resist\u00EAncia a antibi\u00F3ticos beta-lact\u00E2micos como as penicilinas, cefalosporinas, cefamicinas e carbapenemas. Estes antibi\u00F3ticos t\u00EAm como elemento comum em suas estruturas moleculares um anel de quatro \u00E1tomos conhecido como beta-lactama. A enzima lactamase quebra este anel, desativando as propriedades antibacterianas da mol\u00E9cula."@pt . . . . . . . . . "\u03B2-lactamase"@en . "PF00753"@en . . "Les \u03B2-lactamases sont une famille d'enzymes (EC 3.5.2.6) responsables de la r\u00E9sistance de certaines bact\u00E9ries vis-\u00E0-vis de certains antibiotiques b\u00EAta-lactamine. Parmi ces antibiotiques, on trouve les p\u00E9nicillines et les c\u00E9phalosporines. On en retrouve parmi les bact\u00E9ries \u00E0 Gram-n\u00E9gatif, mais pas uniquement."@fr . . "\u03B2-\u5185\u9170\u80FA\u9176\uFF08\u03B2-lactamases\uFF09\uFF0C\u53C8\u7A31\u70BA\u76E4\u5C3C\u897F\u6797\u9176\uFF08Penicillinase\uFF09\u3001\u982D\u5B62\u83CC\u7D20\u9176\uFF08Cephalosporinase\uFF09\uFF0C\u662F\u4E00\u985E\u7531\u67D0\u4E9B\u7EC6\u83CC\u751F\u6210\u6765\u63D0\u4F9B\u591A\u91CD\u6297\u85E5\u6027\uFF0C\u5BF9\u6297\u03B2-\u5185\u9170\u80FA\u7C7B\u6297\u751F\u7D20\uFF08\u6BD4\u5982\u9752\u9709\u7D20\u3001\u5934\u5B62\u83CC\u7D20\u3001\u3001\u78B3\u9752\u9709\u70EF\u7B49\uFF09\u7684\u9176(EC 3.5.2.6)\u3002 \u03B2-\u5185\u9170\u80FA\u7C7B\u6297\u751F\u7D20\u662F\u73B0\u6709\u7684\u6297\u751F\u7D20\u4E2D\u4F7F\u7528\u6700\u5E7F\u6CDB\u7684\u4E00\u7C7B\uFF0C\u901A\u5E38\u517C\u7528\u65BC\u5C0D\u6297\u9769\u862D\u6C0F\u967D\u6027\u83CC\u8207\u9769\u862D\u6C0F\u9670\u6027\u83CC\u3002\u800C\u03B2-\u5185\u9170\u80FA\u9176\u901A\u8FC7\u6253\u7834\u6297\u751F\u7D20\u7684\u5206\u5B50\u7ED3\u6784\u6765\u63D0\u4F9B\u6297\u836F\u6027\u3002\u8FD9\u4E9B\u6297\u751F\u7D20\u7684\u5206\u5B50\u7ED3\u6784\u6709\u4E00\u4E2A\u5171\u540C\u70B9\uFF1A\u79F0\u4E3A\u03B2-\u5185\u9170\u80FA\u7684\u56DB\u5143\u73AF\u6838\u5FC3\u3002\u03B2-\u5185\u9170\u80FA\u9176\u5229\u7528\u6C34\u89E3\u6253\u7834\u4E86\u03B2-\u5185\u9170\u80FA\u56DB\u5143\u73AF\u4F7F\u6297\u751F\u7D20\u5206\u5B50\u5931\u53BB\u836F\u7406\u4F5C\u7528\u3002 \u03B2-\u5185\u9170\u80FA\u9176\u901A\u5E38\u7531\u9769\u5170\u6C0F\u9634\u6027\u83CC\u751F\u6210\uFF0C\u7279\u522B\u662F\u5728\u6709\u6297\u751F\u7D20\u7684\u73AF\u5883\u4E2D\u3002"@zh . . . . "Beta-lactamasa"@ca . . . . "\u0627\u0644\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632: \u0647\u064A \u0627\u0646\u0632\u064A\u0645\u0627\u062A \u062A\u0646\u062A\u062C \u0628\u0648\u0627\u0633\u0637\u0629 \u0628\u0639\u0636 \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u0627 \u0623\u0648 \u0627\u0644\u062C\u0631\u0627\u062B\u064A\u0645 \u0633\u0644\u0628\u064A\u0627\u062A \u063A\u0631\u0627\u0645 \u0648\u0625\u064A\u062C\u0627\u0628\u064A\u0627\u062A \u063A\u0631\u0627\u0645 \u0648\u0647\u064A \u0627\u0644\u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0635\u0641 \u0648\u0627\u0633\u0639 \u0645\u0646 \u0627\u0644\u0645\u0636\u0627\u062F\u0627\u062A \u0627\u0644\u062D\u064A\u0648\u064A\u0629 \u0627\u0644\u0645\u062A\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u060C \u0648\u0627\u0644\u062A\u064A \u0645\u0646\u0647\u0627 \u0627\u0644\u0628\u0646\u0633\u0644\u064A\u0646. \u0648\u062A\u0648\u062C\u062F \u0645\u062C\u0645\u0648\u0639\u0627\u062A \u0648\u0635\u0646\u0648\u0641 \u0639\u062F\u064A\u062F\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0632\u064A\u0645\u0627\u062A \u0627\u0644\u062A\u064A \u062A\u0642\u0627\u0648\u0645 \u0627\u0644\u0645\u0636\u0627\u062F \u0627\u0644\u062D\u064A\u0648\u064A.\u0639\u0644\u0649 \u0633\u0628\u064A\u0644 \u0627\u0644\u0645\u062B\u0627\u0644: \u0635\u0641\u0648\u0641 \u0645\u062A\u0639\u062F\u062F\u0629 \u0645\u0646 \u0623\u0646\u0632\u064A\u0645\u0627\u062A \u00AB\u0633. \u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632\u00BB \u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0633\u064A\u0641\u0627\u0644\u0648\u0633\u0628\u0648\u0631\u064A\u0646 \u0648\u0628\u0639\u0636 \u0635\u0641\u0648\u0641 \u00AB\u0622. \u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632\u00BB \u064A\u0639\u0637\u064A \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u00AB\u0644\u0644\u0623\u0648\u0643\u0633\u064A\u0645\u064A\u0646\u0648 \u0633\u064A\u0641\u0627\u0644\u0648\u0633\u0628\u0648\u0631\u064A\u0646\u0627\u062A\u00BB \u060C \u00AB\u0633\u064A\u0641\u0627\u0645\u064A\u0633\u064A\u0646\u0627\u062A\u00BB \u0648\u0643\u0627\u0631\u0628\u0627\u0628\u064A\u0646\u064A\u0645\u0627\u062A.\u062D\u062F\u064A\u062B\u0627\u064B \u062A\u0645 \u062A\u062D\u062F\u064A\u062F \u0628\u0646\u064A\u062A\u064A\u0646 \u0645\u062E\u062A\u0644\u0641\u064A\u0646 \u0644\u0623\u0646\u0632\u064A\u0645 \u0627\u0644\u0628\u064A\u062A\u0627 \u0644\u0627\u0643\u062A\u0627\u0645\u0627\u0632."@ar . . "\u0392-Lactamasen"@de . . . "Betalactamase"@pt . "CL0013"@en . . "\u03B2-Lactamasen sind Enzyme, die von zahlreichen Bakterien gebildet werden. Sie hydrolysieren einen gemeinsamen strukturellen Bestandteil der \u03B2-Lactam-Antibiotika, den \u03B2-Lactam-Ring, und verhindern dadurch die Wirkung dieser Arzneistoffe. Je nach Ansatzpunkt unterscheidet man zwischen Penicillinasen, Cephalosporinasen und Carbapenemasen. \u03B2-Lactamasen spielen daher eine wichtige Rolle bei der gef\u00FCrchteten Antibiotika-Resistenz von Bakterien. Die genetische Information zur Synthese der \u03B2-Lactamasen wird sowohl chromosomal als auch plasmid\u00E4r vererbt. Hemmstoffe der \u03B2-Lactamasen sind die \u03B2-Lactamase-Inhibitoren."@de . . . . . "Les \u03B2-lactamases sont une famille d'enzymes (EC 3.5.2.6) responsables de la r\u00E9sistance de certaines bact\u00E9ries vis-\u00E0-vis de certains antibiotiques b\u00EAta-lactamine. Parmi ces antibiotiques, on trouve les p\u00E9nicillines et les c\u00E9phalosporines. On en retrouve parmi les bact\u00E9ries \u00E0 Gram-n\u00E9gatif, mais pas uniquement. Le p\u00E9nicillinase est une \u03B2-lactamase montrant une sp\u00E9cificit\u00E9 de substrat pour les p\u00E9nicillines. La p\u00E9nicillinase a \u00E9t\u00E9 la premi\u00E8re \u03B2-lactamase \u00E0 avoir \u00E9t\u00E9 identifi\u00E9e. Elle a \u00E9t\u00E9 isol\u00E9e pour la premi\u00E8re fois par Abraham and Chain en 1940 \u00E0 partir d'Escherichia coli avant m\u00EAme que la p\u00E9nicilline ne soit utilis\u00E9e de mani\u00E8re m\u00E9dicale. La production de p\u00E9nicillinase par les bact\u00E9ries s'est alors rapidement r\u00E9pandue, m\u00EAme par les souches qui ne la produisaient pas pr\u00E9c\u00E9demment gr\u00E2ce au transfert plasmidique d'information g\u00E9n\u00E9tique entre cellules bact\u00E9riennes. Des b\u00EAta-lactamines r\u00E9sistant \u00E0 la p\u00E9nicillinase comme la m\u00E9thicilline ont alors \u00E9t\u00E9 d\u00E9velopp\u00E9s, mais des r\u00E9sistances contre ces mol\u00E9cules sont \u00E9galement apparues."@fr . "Beta-lactamases, (\u03B2-lactamases) are enzymes (EC 3.5.2.6) produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (\u03B2-lactam) ring. Through hydrolysis, the enzyme lactamase breaks the \u03B2-lactam ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to target a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative bacteria are usually secreted, especially when antibiotics are present in the environment."@en . . "300"^^ . . "\u0411\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u0438"@uk . "Structure of Streptomyces albus beta-lactamase"@en . . . . . . . . "CL0381"@en . "Beta-lactamase"@en . . . . . "Beta-laktam\u00E1za"@cs . . "\u0411\u0435\u0442\u0430-\u043B\u0430\u043A\u0442\u0430\u043C\u0430\u0437\u044B"@ru . "Betalactamasa"@es . . . . . 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