. "3.1"^^ . . . "1082487463"^^ . . "Barnase"@en . . "Barnase" . . . . "Barnasi"@it . "Barnasa"@es . "Barnase (a portmanteau of \"BActerial\" \"RiboNucleASE\") is a bacterial protein that consists of 110 amino acids and has ribonuclease activity. It is synthesized and secreted by the bacterium Bacillus amyloliquefaciens, but is lethal to the cell when expressed without its inhibitor barstar. The inhibitor binds to and occludes the ribonuclease active site, preventing barnase from damaging the cell's RNA after it has been synthesized but before it has been secreted. The barnase/barstar complex is noted for its extraordinarily tight protein-protein binding, with an on-rate of 108s\u22121M\u22121."@en . . . . "La barnasi (nome originato dal portmanteau di \"RiboNucleASI\" \"BAtterica\") \u00E8 una proteina batterica dotata di 110 aminoacidi e di un'attivit\u00E0 ribonucleasica. Essa \u00E8 sintetizzata e secreta dal batterio Bacillus amyloliquefaciens, ma \u00E8 al contempo letale per la cellula quando il suo inibitore, il barstar, non \u00E8 espresso. Tale inibitore lega e occlude il sito catalitico ribonucleasico, impedendo alla barnasi di danneggiare l'RNA cellulare nel periodo che intercorre tra la sua traduzione e secrezione. Il complesso barnasi/barstar \u00E8 noto per il suo legame proteina-proteina straordinariamente stretto, con una costante di dissociazione pari a 108s\u22121M\u22121."@it . . . . "\u0411\u0430\u0440\u043D\u0430\u0437\u0430"@ru . . "6068"^^ . . "P00648" . . "\u0411\u0430\u0440\u043D\u0430\u0301\u0437\u0430 \u2014 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0430\u043B\u044C\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A, \u0441\u043E\u0441\u0442\u043E\u044F\u0449\u0438\u0439 \u0438\u0437 110 \u0430\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442. \u041F\u0440\u0438\u043D\u0430\u0434\u043B\u0435\u0436\u0438\u0442 \u043A \u043A\u043B\u0430\u0441\u0441\u0443 \u043D\u0435\u0431\u043E\u043B\u044C\u0448\u0438\u0445 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0430\u043B\u044C\u043D\u044B\u0445 \u0440\u0438\u0431\u043E\u043D\u0443\u043A\u043B\u0435\u0430\u0437. \u0421\u0438\u043D\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044F \u0438 \u0432\u044B\u0434\u0435\u043B\u044F\u0435\u0442\u0441\u044F \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0435\u0439 , \u043D\u043E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0441\u043C\u0435\u0440\u0442\u0435\u043B\u044C\u043D\u044B\u043C \u0434\u043B\u044F \u043A\u043B\u0435\u0442\u043A\u0438, \u0435\u0441\u043B\u0438 \u043D\u0435 \u0441\u0432\u044F\u0437\u0430\u043D \u0438\u043D\u0433\u0438\u0431\u0438\u0442\u043E\u0440\u043E\u043C \u0431\u0430\u0440\u0441\u0442\u0430\u0440\u043E\u043C. \u0411\u0430\u0440\u0441\u0442\u0430\u0440 \u0437\u0430\u043A\u0440\u044B\u0432\u0430\u0435\u0442 \u0430\u043A\u0442\u0438\u0432\u043D\u044B\u0439 \u0446\u0435\u043D\u0442\u0440 \u0431\u0435\u043B\u043A\u0430 \u0438 \u043F\u0440\u0435\u0434\u043E\u0442\u0432\u0440\u0430\u0449\u0430\u0435\u0442 \u043F\u043E\u0432\u0440\u0435\u0436\u0434\u0435\u043D\u0438\u0435 \u043C\u043E\u043B\u0435\u043A\u0443\u043B \u0420\u041D\u041A \u0434\u043E \u0442\u0435\u0445 \u043F\u043E\u0440, \u043F\u043E\u043A\u0430 \u0431\u0430\u0440\u043D\u0430\u0437\u0430 \u043D\u0435 \u0431\u0443\u0434\u0435\u0442 \u0432\u044B\u0432\u0435\u0434\u0435\u043D\u0430 \u0438\u0437 \u0441\u0438\u043D\u0442\u0435\u0437\u0438\u0440\u0443\u044E\u0449\u0435\u0439 \u043A\u043B\u0435\u0442\u043A\u0438. \u041A\u043E\u043C\u043F\u043B\u0435\u043A\u0441 \u0431\u0430\u0440\u043D\u0430\u0437\u044B \u0438 \u0431\u0430\u0440\u0441\u0442\u0430\u0440\u0430 \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u043E\u0434\u043D\u0438\u043C \u0438\u0437 \u0441\u0430\u043C\u044B\u0445 \u043F\u0440\u043E\u0447\u043D\u044B\u0445 \u0431\u0435\u043B\u043E\u043A-\u0431\u0435\u043B\u043A\u043E\u0432\u044B\u0445 \u043A\u043E\u043C\u043F\u043B\u0435\u043A\u0441\u043E\u0432 \u0432 \u043F\u0440\u0438\u0440\u043E\u0434\u0435."@ru . . "Barnasa (Un portmanteau de \"BActerial\" \"RiboNucleASA\") es una prote\u00EDna bacteriana que consta de 110 amino\u00E1cidos y tiene actividad de ribonucleasa. Es sintetizada y secretada por la bacteria Bacillus amyloliquefaciens, pero es letal a la c\u00E9lula cu\u00E1ndo es expresada sin su inhibidor barstar. El inhibidor se une al sitio activo de la ribonucleasa y lo ocluye, impidiendo que la barnasa da\u00F1e el ARN de la c\u00E9lula despu\u00E9s de que se haya sintetizado pero antes de que se haya secretado. El complejo barnasa/barstar se caracteriza por su extraordinaria uni\u00F3n prote\u00EDna-prote\u00EDna, con una tasa de of 108s\u22121M\u22121."@es . . . . . . . . "Barnase"@en . . . . . "1BRS" . . . . . "6253890"^^ . "Barnase"@en . "260"^^ . . . . "La barnasi (nome originato dal portmanteau di \"RiboNucleASI\" \"BAtterica\") \u00E8 una proteina batterica dotata di 110 aminoacidi e di un'attivit\u00E0 ribonucleasica. Essa \u00E8 sintetizzata e secreta dal batterio Bacillus amyloliquefaciens, ma \u00E8 al contempo letale per la cellula quando il suo inibitore, il barstar, non \u00E8 espresso. Tale inibitore lega e occlude il sito catalitico ribonucleasico, impedendo alla barnasi di danneggiare l'RNA cellulare nel periodo che intercorre tra la sua traduzione e secrezione. Il complesso barnasi/barstar \u00E8 noto per il suo legame proteina-proteina straordinariamente stretto, con una costante di dissociazione pari a 108s\u22121M\u22121."@it . "1"^^ . "3.1.27.-" . . "Barnase"@en . . . . "\u0411\u0430\u0440\u043D\u0430\u0301\u0437\u0430 \u2014 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0430\u043B\u044C\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A, \u0441\u043E\u0441\u0442\u043E\u044F\u0449\u0438\u0439 \u0438\u0437 110 \u0430\u043C\u0438\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442. \u041F\u0440\u0438\u043D\u0430\u0434\u043B\u0435\u0436\u0438\u0442 \u043A \u043A\u043B\u0430\u0441\u0441\u0443 \u043D\u0435\u0431\u043E\u043B\u044C\u0448\u0438\u0445 \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0430\u043B\u044C\u043D\u044B\u0445 \u0440\u0438\u0431\u043E\u043D\u0443\u043A\u043B\u0435\u0430\u0437. \u0421\u0438\u043D\u0442\u0435\u0437\u0438\u0440\u0443\u0435\u0442\u0441\u044F \u0438 \u0432\u044B\u0434\u0435\u043B\u044F\u0435\u0442\u0441\u044F \u0431\u0430\u043A\u0442\u0435\u0440\u0438\u0435\u0439 , \u043D\u043E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0441\u043C\u0435\u0440\u0442\u0435\u043B\u044C\u043D\u044B\u043C \u0434\u043B\u044F \u043A\u043B\u0435\u0442\u043A\u0438, \u0435\u0441\u043B\u0438 \u043D\u0435 \u0441\u0432\u044F\u0437\u0430\u043D \u0438\u043D\u0433\u0438\u0431\u0438\u0442\u043E\u0440\u043E\u043C \u0431\u0430\u0440\u0441\u0442\u0430\u0440\u043E\u043C. \u0411\u0430\u0440\u0441\u0442\u0430\u0440 \u0437\u0430\u043A\u0440\u044B\u0432\u0430\u0435\u0442 \u0430\u043A\u0442\u0438\u0432\u043D\u044B\u0439 \u0446\u0435\u043D\u0442\u0440 \u0431\u0435\u043B\u043A\u0430 \u0438 \u043F\u0440\u0435\u0434\u043E\u0442\u0432\u0440\u0430\u0449\u0430\u0435\u0442 \u043F\u043E\u0432\u0440\u0435\u0436\u0434\u0435\u043D\u0438\u0435 \u043C\u043E\u043B\u0435\u043A\u0443\u043B \u0420\u041D\u041A \u0434\u043E \u0442\u0435\u0445 \u043F\u043E\u0440, \u043F\u043E\u043A\u0430 \u0431\u0430\u0440\u043D\u0430\u0437\u0430 \u043D\u0435 \u0431\u0443\u0434\u0435\u0442 \u0432\u044B\u0432\u0435\u0434\u0435\u043D\u0430 \u0438\u0437 \u0441\u0438\u043D\u0442\u0435\u0437\u0438\u0440\u0443\u044E\u0449\u0435\u0439 \u043A\u043B\u0435\u0442\u043A\u0438. \u041A\u043E\u043C\u043F\u043B\u0435\u043A\u0441 \u0431\u0430\u0440\u043D\u0430\u0437\u044B \u0438 \u0431\u0430\u0440\u0441\u0442\u0430\u0440\u0430 \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u043E\u0434\u043D\u0438\u043C \u0438\u0437 \u0441\u0430\u043C\u044B\u0445 \u043F\u0440\u043E\u0447\u043D\u044B\u0445 \u0431\u0435\u043B\u043E\u043A-\u0431\u0435\u043B\u043A\u043E\u0432\u044B\u0445 \u043A\u043E\u043C\u043F\u043B\u0435\u043A\u0441\u043E\u0432 \u0432 \u043F\u0440\u0438\u0440\u043E\u0434\u0435."@ru . . . "Barnasa (Un portmanteau de \"BActerial\" \"RiboNucleASA\") es una prote\u00EDna bacteriana que consta de 110 amino\u00E1cidos y tiene actividad de ribonucleasa. Es sintetizada y secretada por la bacteria Bacillus amyloliquefaciens, pero es letal a la c\u00E9lula cu\u00E1ndo es expresada sin su inhibidor barstar. El inhibidor se une al sitio activo de la ribonucleasa y lo ocluye, impidiendo que la barnasa da\u00F1e el ARN de la c\u00E9lula despu\u00E9s de que se haya sintetizado pero antes de que se haya secretado. El complejo barnasa/barstar se caracteriza por su extraordinaria uni\u00F3n prote\u00EDna-prote\u00EDna, con una tasa de of 108s\u22121M\u22121."@es . "P00648"@en . . . . . . . . "La barnase est une ribonucl\u00E9ase bact\u00E9rienne de 110 r\u00E9sidus d'acides amin\u00E9s ; le nom \u00AB barnase \u00BB est un mot-valise pour l'anglais bacterial RNase. Cette enzyme catalyse le clivage de l'ARN \u00E0 la suite d'un r\u00E9sidu de guanosine, c'est-\u00E0-dire sur son c\u00F4t\u00E9 3\u2019. La catalyse emploie un m\u00E9canisme acide-base faisant intervenir les r\u00E9sidus de glutamate Glu73 et d'histidine His102, le premier comme base et le second comme acide. Le r\u00E9sidu de lysine Lys27 est \u00E9galement indispensable \u00E0 l'activit\u00E9 enzymatique en se liant \u00E0 l'\u00E9tat de transition du substrat, et ce bien qu'il n'intervienne pas directement dans la catalyse. La barnase est synth\u00E9tis\u00E9e et s\u00E9cr\u00E9t\u00E9e par la Bacillus amyloliquefaciens, une bact\u00E9rie. Elle est l\u00E9tale pour la cellule lorsqu'elle n'est pas exprim\u00E9e avec son inhibiteur, la barstar, une prot\u00E9ine qui forme avec cette enzyme un complexe \u00E0 l'interaction prot\u00E9ine-prot\u00E9ine particuli\u00E8rement forte tant que l'ensemble demeure dans le cytoplasme. Cet inhibiteur couvre le site actif de l'enzyme, ce qui emp\u00EAche cette derni\u00E8re de d\u00E9grader l'ARN \u00E0 l'int\u00E9rieur de la cellule. La barnase n'a pas de pont disulfure et n'a besoin d'aucun cation m\u00E9tallique divalent ni de groupe prosth\u00E9tique pour adopter la conformation de son \u00E9tat natif. Elle a par cons\u00E9quent fait l'objet de nombreuses recherches pour comprendre les m\u00E9canismes du repliement des prot\u00E9ines."@fr . . . . . . . "Barnase (a portmanteau of \"BActerial\" \"RiboNucleASE\") is a bacterial protein that consists of 110 amino acids and has ribonuclease activity. It is synthesized and secreted by the bacterium Bacillus amyloliquefaciens, but is lethal to the cell when expressed without its inhibitor barstar. The inhibitor binds to and occludes the ribonuclease active site, preventing barnase from damaging the cell's RNA after it has been synthesized but before it has been secreted. The barnase/barstar complex is noted for its extraordinarily tight protein-protein binding, with an on-rate of 108s\u22121M\u22121."@en . . . . . . . . . . "Barnase"@fr . . . "La barnase est une ribonucl\u00E9ase bact\u00E9rienne de 110 r\u00E9sidus d'acides amin\u00E9s ; le nom \u00AB barnase \u00BB est un mot-valise pour l'anglais bacterial RNase. Cette enzyme catalyse le clivage de l'ARN \u00E0 la suite d'un r\u00E9sidu de guanosine, c'est-\u00E0-dire sur son c\u00F4t\u00E9 3\u2019. La catalyse emploie un m\u00E9canisme acide-base faisant intervenir les r\u00E9sidus de glutamate Glu73 et d'histidine His102, le premier comme base et le second comme acide. Le r\u00E9sidu de lysine Lys27 est \u00E9galement indispensable \u00E0 l'activit\u00E9 enzymatique en se liant \u00E0 l'\u00E9tat de transition du substrat, et ce bien qu'il n'intervienne pas directement dans la catalyse."@fr . . . . . . "The tightly bound complex between barnase and its inhibitor barstar. Barnase is colored by secondary structure and barstar is colored in blue."@en .