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Statements

Subject Item
dbr:Tracy_(sheep)
rdfs:label
Tracy (sheep)
rdfs:comment
Tracy (1990 – 1997) was a transgenically modified sheep created by scientists at Scotland's Roslin Institute to produce the human protein alpha 1-antitrypsin, a substance regarded in the 1990s as a potential pharmaceutical for the treatments of cystic fibrosis and emphysema. Notably, she is the first transgenic farm mammal ever created.
dcterms:subject
dbc:Individual_animals_in_the_United_Kingdom dbc:1997_animal_deaths dbc:1990_animal_births dbc:Cloned_sheep
dbo:wikiPageID
42555506
dbo:wikiPageRevisionID
1082023475
dbo:wikiPageWikiLink
dbr:Pharming_(genetics) dbr:Genetically_modified_organisms dbr:Genetically_modified_organism dbr:Cystic_fibrosis dbr:Roslin_Institute dbc:1990_animal_births dbr:Dolly_(sheep) dbc:Cloned_sheep dbr:Alpha_1-antitrypsin dbr:Emphysema dbc:1997_animal_deaths dbc:Individual_animals_in_the_United_Kingdom
owl:sameAs
freebase:m.010ffdw0 yago-res:Tracy_(sheep) n13:eUVZ wikidata:Q16910432
dbo:abstract
Tracy (1990 – 1997) was a transgenically modified sheep created by scientists at Scotland's Roslin Institute to produce the human protein alpha 1-antitrypsin, a substance regarded in the 1990s as a potential pharmaceutical for the treatments of cystic fibrosis and emphysema. Notably, she is the first transgenic farm mammal ever created. Alpha 1-antitrypsin comprised 50% of the total protein in Tracy's milk, a remarkably high level maintained after lactation. Similar levels were detected in the milk produced by her granddaughters. A deficiency in this protein in humans can produce lung diseases, and its artificial creation was thought to be a potential success in the diseases' treatment. Clinical trials for the engineered protein in 1998 revealed that it developed breathing problems in patients, and research for the milk as a remedy for the diseases has not continued since then.
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wikipedia-en:Tracy_(sheep)?oldid=1082023475&ns=0
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2203
foaf:isPrimaryTopicOf
wikipedia-en:Tracy_(sheep)