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Statements

Subject Item
dbr:Ro_3-0419
rdf:type
n12:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 owl:Thing dbo:ChemicalCompound
rdfs:label
Ro 3-0419
rdfs:comment
Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It is the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, resulting in its ability to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.
foaf:name
Ro 3-0419
dbp:name
Ro 3-0419
foaf:depiction
n13:Ro_3-0419.svg
dcterms:subject
dbc:Organophosphates dbc:Quinolines dbc:Acetylcholinesterase_inhibitors dbc:Ethyl_esters
dbo:wikiPageID
58993447
dbo:wikiPageRevisionID
1022856309
dbo:wikiPageWikiLink
dbc:Organophosphates dbr:Blood_brain_barrier dbc:Quinolines dbr:Acetylcholinesterase_inhibitor dbc:Ethyl_esters dbr:Ro_3-0422 dbc:Acetylcholinesterase_inhibitors dbr:Organophosphate
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dbt:Acetylcholine_metabolism_and_transport_modulators dbt:Reflist dbt:Organic-compound-stub dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Short_description dbt:Chembox dbt:LD50 dbt:Chembox_Properties
dbo:thumbnail
n13:Ro_3-0419.svg?width=300
dbp:imagefile
Ro 3-0419.svg
dbp:othernames
3
dbp:pin
Diethyl quinolin-3-yl phosphate
dbo:abstract
Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It is the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, resulting in its ability to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.
prov:wasDerivedFrom
wikipedia-en:Ro_3-0419?oldid=1022856309&ns=0
dbo:wikiPageLength
1673
dbo:alternativeName
3-(Diethoxyphosphinyloxy)-quinoline
dbo:iupacName
Diethyl quinolin-3-yl phosphate
foaf:isPrimaryTopicOf
wikipedia-en:Ro_3-0419