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Statements

Subject Item
dbr:Renin_stability_regulatory_element_(REN-SRE)
rdf:type
yago:PsychologicalFeature100023100 yago:Abstraction100002137 yago:Idea105833840 yago:Concept105835747 yago:Part105867413 yago:Cognition100023271 dbo:MilitaryUnit yago:Content105809192 yago:Component105868954 yago:WikicatCis-regulatoryRNAElements
rdfs:label
Renin stability regulatory element (REN-SRE)
rdfs:comment
The Renin stability regulatory element (REN-SRE) is a cis-acting element identified in the 3'untranslated region (3'UTR) of the renin (REN) gene. It acts to regulate the levels of renin protein produced in the cell. Renin is secreted by renal juxtaglomerular cells and catalyses the conversion of angiotensinogen into angiotensin I which is the rate-limiting step in the production of angiotensin II. Angiotensin II induces hypertension and REN therefore requires tight expression control.
dbp:name
Renin stability regulatory element
foaf:depiction
n14:RF00180.jpg
dcterms:subject
dbc:Cis-regulatory_RNA_elements
dbo:wikiPageID
11421399
dbo:wikiPageRevisionID
951589882
dbo:wikiPageWikiLink
dbr:Sequence_conservation dbr:Secondary_structure dbr:Eukaryota dbr:Juxtaglomerular_cell dbr:Cis-acting_element dbr:Catalyse dbc:Cis-regulatory_RNA_elements dbr:Translation_(biology) dbr:Renin dbr:Angiotensinogen dbr:Cis-regulatory_element dbr:Hypertension dbr:3'_UTR dbr:MRNA
owl:sameAs
freebase:m.02rbzyz wikidata:Q7313254 n17:4toWP yago-res:Renin_stability_regulatory_element_(REN-SRE)
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dbo:thumbnail
n14:RF00180.jpg?width=300
dbp:caption
Predicted secondary structure and sequence conservation of REN-SRE
dbp:id
RF00180
dbp:symbol
REN-SRE
dbo:abstract
The Renin stability regulatory element (REN-SRE) is a cis-acting element identified in the 3'untranslated region (3'UTR) of the renin (REN) gene. It acts to regulate the levels of renin protein produced in the cell. Renin is secreted by renal juxtaglomerular cells and catalyses the conversion of angiotensinogen into angiotensin I which is the rate-limiting step in the production of angiotensin II. Angiotensin II induces hypertension and REN therefore requires tight expression control. REN-SRE is thought to act by destabilising the REN messenger RNA (mRNA) and promoting degradation of the mRNA sequence. It has been found that a number of proteins bind to the REN-SRE to stabilise the mRNA and promote translation.
dbp:rfam
RF00180
dbp:rnaType
dbr:Cis-regulatory_element
gold:hypernym
dbr:Element
prov:wasDerivedFrom
wikipedia-en:Renin_stability_regulatory_element_(REN-SRE)?oldid=951589882&ns=0
dbo:wikiPageLength
2007
foaf:isPrimaryTopicOf
wikipedia-en:Renin_stability_regulatory_element_(REN-SRE)