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Statements

Subject Item
dbr:PA_clan_of_proteases
rdf:type
dbo:Biomolecule dbo:Protein wikidata:Q206229 owl:Thing wikidata:Q8054
rdfs:label
PA clan of proteases
rdfs:comment
The PA clan (Proteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology. Members have a chymotrypsin-like fold and similar proteolysis mechanisms but can have identity of <10%. The clan contains both cysteine and serine proteases (different nucleophiles). PA clan proteases can be found in plants, animals, fungi, eubacteria, archaea and viruses.
rdfs:seeAlso
dbr:Cysteine_hydrolase_mechanisms dbr:Catalytic_triad
dbp:name
PA clan of proteases
foaf:depiction
n10:Viral_protease_loop.png n10:TEV_protease_beta-barrels.png n10:Triad_Divergence.png n10:PA_clan_vs_C04_family_sequence_conservation.png n10:PA_clan_structures_10.png
dcterms:subject
dbc:Protein_superfamilies dbc:Proteases dbc:Molecular_evolution dbc:EC_3.4
dbo:wikiPageID
40763842
dbo:wikiPageRevisionID
1043905951
dbo:wikiPageWikiLink
dbr:Β-barrel dbr:Archaea dbr:Saccharomyces_cerevisiae dbr:Staphylococcus_aureus dbr:Pit_viper dbr:Nucleophile dbr:Thrombin dbr:Rabbit_hemorrhagic_disease dbr:Potyvirus_P1_peptidase n5:Viral_protease_loop.png dbr:Haemotoxin dbr:Trypsin dbr:Cocksfoot_mottle_virus dbr:Transmissible_gastroenteritis_virus dbr:Catalytic_triad dbr:Fungi dbr:Sobemovirus_peptidase dbr:Nucleophiles dbr:Cysteine dbr:Picornavirus dbr:Chymotrypsin dbr:White_bream_virus dbr:Tobacco_etch_virus dbc:Proteases dbr:Tobacco_etch_virus_protease dbr:Azurocidin_1 dbr:Blood_clotting dbr:Polio dbr:Porphyromonas_gingivalis dbr:Cysteine_protease dbr:Threonine_protease dbr:Exfoliatin dbr:Southampton_virus dbr:Norovirus dbr:Structural_homology dbr:Aspartic_protease dbr:TEV_protease dbr:Exopeptidases dbr:Families_of_structurally_similar_proteins dbr:Specificity_(biochemistry) dbr:Bos_taurus dbr:Protein_structure dbr:Enzyme_catalysis dbc:Protein_superfamilies dbr:Protein_superfamily dbr:Heparin dbr:Flavivirin dbr:DPP7 dbr:S1_family dbr:Genome dbr:Serine_proteases dbr:Homology_(biology) dbr:Metalloprotease dbr:Proteolysis dbr:Convergent_evolution dbr:Sindbis_virus dbr:Poliovirus n5:Triad_Divergence.png dbr:Endopeptidases dbr:Serine dbr:Hepacivirin dbr:Torovirus dbr:Equine_viral_arteritis dbr:SpoIVB_peptidase dbr:Structural_alignment dbr:Gill-associated_virus dbr:Togavirin dbr:Calicivirin dbc:Molecular_evolution dbr:Sequence_similarity dbr:Virus dbr:Directed_evolution dbr:Animals dbr:Active_site dbr:Plants dbr:Divergent_evolution dbr:Picornain_3C dbr:Peptidase_Do dbr:Protein_crystallography dbr:Digestion dbr:West_nile_virus dbr:Protein_family dbr:Viruses dbr:Snake_venoms dbr:Protein_dynamics dbr:Equine_arteritis_virus dbr:Equine_arterivirus_serine_peptidase dbr:Pseudoenzymes dbr:Chloroplast dbr:IgA_specific_serine_endopeptidase dbr:Protease dbr:Cavally_virus dbr:Nucleophilic_catalysis dbr:Pestivirus_NS3_polyprotein_peptidase dbr:Trimeresurus_stejnegeri dbr:Yellow_fever_virus dbr:Serine_protease dbr:Neisseria_gonorrhoeae dbr:Eukaryote dbr:Beta_barrel dbr:MEROPS dbr:Hepatitis_C_virus dbr:Prokaryote dbr:Bacillus_subtilis dbr:3C-like_protease dbr:Bovine_viral_diarrhea dbc:EC_3.4 dbr:Tobacco_Etch_Virus_protease dbr:Eubacteria dbr:Plum_pox_virus
dbo:wikiPageExternalLink
n14:clansum%3Fclan=PA n15:genome.cgi%3Fsf=50494&cgi_up=yes
owl:sameAs
n8:2LFE4 wikidata:Q24783967
dbp:wikiPageUsesTemplate
dbt:Enzymes dbt:Portal dbt:Wide_image dbt:See_also dbt:PDB dbt:Proteases dbt:Pfam_box dbt:Reflist dbt:Colend dbt:Colbegin
dbo:thumbnail
n10:TEV_protease_beta-barrels.png?width=300
dbp:scop
50494
dbp:caption
The double β-barrels that characterise the PA clan are highlighted in red.
dbp:interpro
IPR009003
dbp:pfamClan
CL0124
dbp:symbol
N/A
dbp:width
250
dbo:abstract
The PA clan (Proteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology. Members have a chymotrypsin-like fold and similar proteolysis mechanisms but can have identity of <10%. The clan contains both cysteine and serine proteases (different nucleophiles). PA clan proteases can be found in plants, animals, fungi, eubacteria, archaea and viruses. The common use of the catalytic triad for hydrolysis by multiple clans of proteases, including the PA clan, represents an example of convergent evolution. The differences in the catalytic triad within the PA clan is also an example of divergent evolution of active sites in enzymes.
dbp:membranomeSuperfamily
319
prov:wasDerivedFrom
wikipedia-en:PA_clan_of_proteases?oldid=1043905951&ns=0
dbo:wikiPageLength
19456
dbo:symbol
N/A
foaf:isPrimaryTopicOf
wikipedia-en:PA_clan_of_proteases