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Statements

Subject Item
dbr:Grainyhead-like_gene_family
rdfs:label
Grainyhead-like gene family
rdfs:comment
Grainyhead-like genes are a family of highly conserved transcription factors that are functionally and structurally homologous across a large number of vertebrate and invertebrate species. For an estimated 100 million years or more, this genetic family has been evolving alongside life to fine tune the regulation of epithelial barrier integrity during development, fine-tuning epithelial barrier establishment, maintenance and subsequent homeostasis. The three main orthologues, Grainyhead-like 1, 2 and 3, regulate numerous genetic pathways within different organisms and perform analogous roles between them, ranging from neural tube closure, wound healing, establishment of the craniofacial skeleton and repair of the epithelium. When Grainyhead-like genes are impaired, due to genetic mutations
foaf:depiction
n4:Craniofacial_defects_in_grhl3_knockdown_zebrafish.png n4:Grhl3_KO_skull_comparison(1).png
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dbc:Protein_families
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63194019
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1047694418
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dbr:Transcription_factor n7:Abdominal_wall n7:Cell_wall n7:Cleft_lip_and_cleft_palate dbr:Protein_family n7:Craniofacial n7:Cranioschisis n7:Apoptosis n7:Birth_defect n7:Breast_cancer n7:Cadherin n7:Epidermis n7:Epithelial–mesenchymal_transition n7:Exencephaly n7:Van_der_Woude_syndrome n7:Hearing_loss n7:Xenopus n7:DSG1 n7:Yolk_sac n7:Desmosome n7:Zebrafish n7:Drosophila n7:Immune_system n7:Epiboly n7:Neural_tube n7:Sea_urchin n7:Spina_bifida dbr:Anxiety dbc:Protein_families n15:defect dbr:Endoderm n7:transcription_factor n18:Grhl3_KO_skull_comparison(1).png n18:Craniofacial_defects_in_grhl3_knockdown_zebrafish.png
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n4:Grhl3_KO_skull_comparison(1).png?width=300
dbo:abstract
Grainyhead-like genes are a family of highly conserved transcription factors that are functionally and structurally homologous across a large number of vertebrate and invertebrate species. For an estimated 100 million years or more, this genetic family has been evolving alongside life to fine tune the regulation of epithelial barrier integrity during development, fine-tuning epithelial barrier establishment, maintenance and subsequent homeostasis. The three main orthologues, Grainyhead-like 1, 2 and 3, regulate numerous genetic pathways within different organisms and perform analogous roles between them, ranging from neural tube closure, wound healing, establishment of the craniofacial skeleton and repair of the epithelium. When Grainyhead-like genes are impaired, due to genetic mutations in embryogenesis, it will cause the organism to present with developmental defects that largely affect ectodermal (and sometimes also endodermal) tissues in which they are expressed. These subsequent congenital disorders, including cleft lip and exencephaly, vary greatly in their severity and impact on the quality of life for the affected individual. There is much still to learn about the function of these genes and the more complex roles of Grainyhead-like genes are yet to be discovered.
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wikipedia-en:Grainyhead-like_gene_family