This HTML5 document contains 70 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
yago-reshttp://yago-knowledge.org/resource/
dbohttp://dbpedia.org/ontology/
foafhttp://xmlns.com/foaf/0.1/
n5http://dbpedia.org/resource/Arp2/
n14https://global.dbpedia.org/id/
yagohttp://dbpedia.org/class/yago/
dbthttp://dbpedia.org/resource/Template:
dbpedia-ukhttp://uk.dbpedia.org/resource/
rdfshttp://www.w3.org/2000/01/rdf-schema#
freebasehttp://rdf.freebase.com/ns/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n17http://tt.dbpedia.org/resource/
wikipedia-enhttp://en.wikipedia.org/wiki/
provhttp://www.w3.org/ns/prov#
dbphttp://dbpedia.org/property/
dbchttp://dbpedia.org/resource/Category:
xsdhhttp://www.w3.org/2001/XMLSchema#
wikidatahttp://www.wikidata.org/entity/
goldhttp://purl.org/linguistics/gold/
dbrhttp://dbpedia.org/resource/

Statements

Subject Item
dbr:FGD1
rdf:type
yago:Thing100002452 dbo:HumanGene yago:Abstraction100002137 yago:OrganicCompound114727670 wikidata:Q206229 yago:WikicatHumanProteins yago:Molecule114682133 dbo:Biomolecule wikidata:Q7187 yago:Chemical114806838 yago:Compound114818238 yago:Substance100019613 yago:Material114580897 yago:Protein114728724 dbo:Protein yago:Matter100020827 owl:Thing yago:Macromolecule114944888 yago:Part113809207 dbo:Gene yago:PhysicalEntity100001930 yago:Unit109465459 yago:Relation100031921
rdfs:label
FGD1 FGD1
rdfs:comment
FGD1 (англ. FYVE, RhoGEF and PH domain containing 1) – білок, який кодується однойменним геном, розташованим у людей на X-хромосомі. Довжина поліпептидного ланцюга білка становить 961 амінокислот, а молекулярна маса — 106 561. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome. Orthologs of the FGD1 gene are found in dog, cow, mouse, rat, and zebrafish, and also budding yeast and C. elegans. It is a member of the FYVE, RhoGEF and PH domain containing family.
dcterms:subject
dbc:Human_proteins
dbo:wikiPageID
12044577
dbo:wikiPageRevisionID
1116526693
dbo:wikiPageWikiLink
n5:3_complex dbr:Eukaryote dbr:PH_domain dbr:RhoGEF_domain dbr:Homology_(biology) dbr:Gene dbr:Caenorhabditis_elegans dbr:YOTB dbr:FYVE,_RhoGEF_and_PH_domain_containing dbr:FYVE_domain dbr:EEA1 dbr:Phosphatidylinositol_3-phosphate dbr:Cortactin dbr:Vac1 dbr:Golgi_apparatus dbr:Fab1 dbr:Protein dbr:Filopodia dbr:C-Jun_N-terminal_kinase dbr:CDC42 dbc:Human_proteins dbr:Aarskog-Scott_syndrome dbr:Guanine-nucleotide_exchange_factor dbr:3T3_cells
owl:sameAs
wikidata:Q15311768 n14:XLJP dbpedia-uk:FGD1 freebase:m.03gy7p8 n17:FGD1 yago-res:FGD1
dbp:wikiPageUsesTemplate
dbt:Short_description dbt:Reflist dbt:Infobox_gene dbt:GTP-binding_protein_regulators
dbo:abstract
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein that in humans is encoded by the FGD1 gene that lies on the X chromosome. Orthologs of the FGD1 gene are found in dog, cow, mouse, rat, and zebrafish, and also budding yeast and C. elegans. It is a member of the FYVE, RhoGEF and PH domain containing family. FGD1 is a guanine-nucleotide exchange factor (GEF) that can activate the Rho GTPase Cdc42. It localizes preferentially to the trans-Golgi network (TGN) of mammalian cells and regulates, for example, the secretory transport of bone-specific proteins from the Golgi complex. Thus Cdc42 and FGD1 regulate secretory membrane trafficking that occurs especially during bone growth and mineralization in humans. FGD1 promotes nucleotide exchange on the GTPase Cdc42, a key player in the establishment of cell polarity in all eukaryotic cells. The GEF activity of FGD1, which activates Cdc42, is harbored in its DH domain and causes the formation of filopodia, enabling the cells to migrate. FGD1 also activates the c-Jun N-terminal kinase (JNK) signaling cascade, important in cell differentiation and apoptosis. It also promotes the transition through G1 during the cell cycle and causes tumorgenic transformation of NIH/3T3 fibroblasts. The FGD1 gene is located on the short arm of the X-chromosome and is essential for normal mammalian embryonic development. Mice embryos that carried experimentally introduced mutations in the FGD1 gene had skeletal abnormalities affecting bone size, cartilage growth, vertebrae formation and distal extremities. These severe phenotypes are consistent with a lack of Cdc42 activity, as it controls membrane traffic as well as the organization of the actin cytoskeleton. Mutations in the FGD1 gene that cause the production of non-functional proteins are responsible for the severe phenotype of the X-linked disorder faciogenital dysplasia (FGDY), also called Aarskog-Scott syndrome. FGD1 (англ. FYVE, RhoGEF and PH domain containing 1) – білок, який кодується однойменним геном, розташованим у людей на X-хромосомі. Довжина поліпептидного ланцюга білка становить 961 амінокислот, а молекулярна маса — 106 561. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до фосфопротеїнів. Білок має сайт для зв'язування з іонами металів, іоном цинку. Локалізований у цитоплазмі, цитоскелеті, клітинних відростках.
gold:hypernym
dbr:Protein
prov:wasDerivedFrom
wikipedia-en:FGD1?oldid=1116526693&ns=0
dbo:wikiPageLength
12661
foaf:isPrimaryTopicOf
wikipedia-en:FGD1