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Statements

Subject Item
dbr:Β-LGND2
rdf:type
wikidata:Q8386 dbo:Drug dbo:ChemicalSubstance n15:ChemicalObject owl:Thing
rdfs:label
Β-LGND2
rdfs:comment
β-LGND2, also known as ERβ-selective ligand 2 or as GTx-878, is a synthetic nonsteroidal estrogen and selective ERβ agonist which was under development by GTx for the treatment of benign prostatic hyperplasia, prostatitis, and rheumatoid arthritis but was never marketed. It shows approximately 25-fold selectivity for activation of the ERβ over the ERα (EC50 = 2 nM and 52 nM, respectively). β-LGND2 is an isoquinolinone derivative.
foaf:depiction
n9:Β-LGND2.svg
dcterms:subject
dbc:Abandoned_drugs dbc:Phenols dbc:Bromoarenes dbc:Selective_ERβ_agonists dbc:Triols dbc:Isoquinolines dbc:Ketones dbc:Synthetic_estrogens
dbo:wikiPageID
57760778
dbo:wikiPageRevisionID
1086672368
dbo:wikiPageWikiLink
dbc:Synthetic_estrogens dbr:Prostatitis dbr:ERβ dbr:Synthetic_compound dbr:ERα dbr:Chemical_derivative dbc:Abandoned_drugs dbr:Benign_prostatic_hyperplasia dbc:Phenols dbc:Bromoarenes dbc:Selective_ERβ_agonists dbr:Agonist dbr:Rheumatoid_arthritis dbr:GTx_Incorporated dbr:Isoquinoline dbc:Triols dbc:Ketones dbr:Nonsteroidal_estrogen dbr:Binding_selectivity dbc:Isoquinolines
dbo:wikiPageExternalLink
n16:800027855
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wikidata:Q55638313 n13:5S1oR
dbp:wikiPageUsesTemplate
dbt:Estrogen_receptor_modulators dbt:Short_description dbt:Drugbox dbt:Abbrlink dbt:Reflist
dbo:thumbnail
n9:Β-LGND2.svg?width=300
dbp:br
1
dbp:c
15
dbp:casNumber
1462971
dbp:casSupplemental
1644567
dbp:class
Nonsteroidal estrogen; Selective ERβ agonist
dbp:h
10
dbp:iupacName
4
dbp:n
1
dbp:o
4
dbp:pubchem
24962206
dbp:smiles
C1=CCO
dbp:stdinchi
1
dbp:stdinchikey
GLVQMSCCFOGRRG-UHFFFAOYSA-N
dbp:synonyms
β-LGND2; ER-β-selective ligand 2
dbo:abstract
β-LGND2, also known as ERβ-selective ligand 2 or as GTx-878, is a synthetic nonsteroidal estrogen and selective ERβ agonist which was under development by GTx for the treatment of benign prostatic hyperplasia, prostatitis, and rheumatoid arthritis but was never marketed. It shows approximately 25-fold selectivity for activation of the ERβ over the ERα (EC50 = 2 nM and 52 nM, respectively). β-LGND2 is an isoquinolinone derivative.
prov:wasDerivedFrom
wikipedia-en:Β-LGND2?oldid=1086672368&ns=0
dbo:wikiPageLength
5089
dbo:casNumber
1462971-30-7 1644567-26-9
dbo:pubchem
24962206
dbo:class
dbr:Nonsteroidal_estrogen
foaf:isPrimaryTopicOf
wikipedia-en:Β-LGND2