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- In enzymology, a cholesterol 7alpha-monooxygenase (EC 1.14.13.17) is an enzyme that catalyzes the chemical reaction cholesterol + NADPH + H+ + O2 7alpha-hydroxycholesterol + NADP+ + H2O The 4 substrates of this enzyme are cholesterol, NADPH, H+, and O2, whereas its 3 products are 7-alpha-hydroxycholesterol, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating). Other names in common use include cholesterol 7alpha-hydroxylase, and CYP7A1. This enzyme participates in bile acid biosynthesis and ppar signaling pathway. It employs one cofactor, heme. (en)
- コレステロール-7α-モノオキシゲナーゼ（cholesterol 7-α-monooxygenase）は、ステロイドホルモン生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 コレステロール + NADPH + H+ + O2 7α-ヒドロキシコレステロール + NADP+ + H2O この酵素の基質はコレステロール、NADPH、H+とO2で、生成物は7α-ヒドロキシコレステロール、NADP+とH2Oである。補酵素としてヘムを用いる。 組織名はcholesterol,NADPH:oxygen oxidoreductase (7α-hydroxylating)で、別名にcholesterol 7α-hydroxylase、CYP7A1がある。 (ja)
- La colesterolo 7alfa-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: colesterolo + NADPH + H+ + O2 ⇄ 7α-idrossicolesterolo + NADP+ + H2O L'enzima è una proteina eme-tiolata (P-450). (it)
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- 2811 (xsd:nonNegativeInteger)
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- cholesterol 7-alpha-monooxygenase (en)
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- コレステロール-7α-モノオキシゲナーゼ（cholesterol 7-α-monooxygenase）は、ステロイドホルモン生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 コレステロール + NADPH + H+ + O2 7α-ヒドロキシコレステロール + NADP+ + H2O この酵素の基質はコレステロール、NADPH、H+とO2で、生成物は7α-ヒドロキシコレステロール、NADP+とH2Oである。補酵素としてヘムを用いる。 組織名はcholesterol,NADPH:oxygen oxidoreductase (7α-hydroxylating)で、別名にcholesterol 7α-hydroxylase、CYP7A1がある。 (ja)
- La colesterolo 7alfa-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: colesterolo + NADPH + H+ + O2 ⇄ 7α-idrossicolesterolo + NADP+ + H2O L'enzima è una proteina eme-tiolata (P-450). (it)
- In enzymology, a cholesterol 7alpha-monooxygenase (EC 1.14.13.17) is an enzyme that catalyzes the chemical reaction cholesterol + NADPH + H+ + O2 7alpha-hydroxycholesterol + NADP+ + H2O The 4 substrates of this enzyme are cholesterol, NADPH, H+, and O2, whereas its 3 products are 7-alpha-hydroxycholesterol, NADP+, and H2O. (en)
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- Cholesterol 7alpha-monooxygenase (en)
- Colesterolo 7alfa-monoossigenasi (it)
- コレステロール-7α-モノオキシゲナーゼ (ja)
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- cholesterol 7-alpha-monooxygenase (en)
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