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- Die Sterol-26-Hydroxylase (CYP27) (auch Cholestantriol-26-Monooxygenase oder Cytochrom P450 27/25) ist ein mitochondriales Enzym, welches für den Abbau der Cholesterine zu Gallensäuren wichtig ist und zusammen mit Cytochrom P450 2R1 das Vitamin D3 zu 25(OH)Vitamin D3 hydroxyliert (es hat die Enzymfunktion Vitamin D3 25-Hydroxylase). Mutationen am CYP27A1-Gen sind für eine bestimmte Form der Xanthomatose verantwortlich. (de)
- In enzymology, a cholestanetriol 26-monooxygenase (EC 1.14.13.15) is an enzyme that catalyzes the chemical reaction 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O The 4 substrates of this enzyme are , NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating). Other names in common use include 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, sterol 27-hydroxylase, sterol 26-hydroxylase, cholesterol 27-hydroxylase, CYP27A, CYP27A1, and cytochrome P450 27A1'. This enzyme participates in bile acid biosynthesis and . (en)
- コレスタントリオール-26-モノオキシゲナーゼ（cholestanetriol 26-monooxygenase）は、次の化学反応を触媒する酸化還元酵素である。 5β-コレスタン-3α,7α,12α-トリオール + NADPH + H+ + O2 (25R)-5β-コレスタン-3α,7α,12α,26-テトラオール + NADP+ + H2O この酵素の基質は、NADPH、H+とO2で、生成物は、NADP+とH2Oである。 組織名は5β-cholestane-3α,7α,12α-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)で、別名に5β-cholestane-3α,7α,12α-triol 26-hydroxylase、5β-cholestane-3α,7α,12α-triol hydroxylase、cholestanetriol 26-hydroxylase、sterol 27-hydroxylase、sterol 26-hydroxylase、cholesterol 27-hydroxylase、CYP27A、CYP27A1、cytochrome P450 27A1'がある。 (ja)
- La colestanotriolo 26-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5β-colestan-3α,7α,12α-triolo + NADPH + H+ + O2 ⇄ (25R)-5β-colestan-3α,7α,12α,26-tetraolo + NADP+ + H2O L'enzima richiede ferrodossina. Agisce sul colesterolo, sul colest-5-en-3β,7α-diolo, 7α-idrossicolest-4-en-3-one, 5β-colestan-3α,7α-diolo così come sul 5β-colestan-3α,7α,12α-triolo. Con il colesterolo così come con il 26-idrossicolesterolo, vengono prodotti il 24-idrossi- e 25-idrossicolesterolo. Con un trattamento prolungato, il 26-idrossicolesterolo è convertito nella corrispondente 27-aldeide e nell'acido 27-oico. (it)
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- Die Sterol-26-Hydroxylase (CYP27) (auch Cholestantriol-26-Monooxygenase oder Cytochrom P450 27/25) ist ein mitochondriales Enzym, welches für den Abbau der Cholesterine zu Gallensäuren wichtig ist und zusammen mit Cytochrom P450 2R1 das Vitamin D3 zu 25(OH)Vitamin D3 hydroxyliert (es hat die Enzymfunktion Vitamin D3 25-Hydroxylase). Mutationen am CYP27A1-Gen sind für eine bestimmte Form der Xanthomatose verantwortlich. (de)
- コレスタントリオール-26-モノオキシゲナーゼ（cholestanetriol 26-monooxygenase）は、次の化学反応を触媒する酸化還元酵素である。 5β-コレスタン-3α,7α,12α-トリオール + NADPH + H+ + O2 (25R)-5β-コレスタン-3α,7α,12α,26-テトラオール + NADP+ + H2O この酵素の基質は、NADPH、H+とO2で、生成物は、NADP+とH2Oである。 組織名は5β-cholestane-3α,7α,12α-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)で、別名に5β-cholestane-3α,7α,12α-triol 26-hydroxylase、5β-cholestane-3α,7α,12α-triol hydroxylase、cholestanetriol 26-hydroxylase、sterol 27-hydroxylase、sterol 26-hydroxylase、cholesterol 27-hydroxylase、CYP27A、CYP27A1、cytochrome P450 27A1'がある。 (ja)
- In enzymology, a cholestanetriol 26-monooxygenase (EC 1.14.13.15) is an enzyme that catalyzes the chemical reaction 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O The 4 substrates of this enzyme are , NADPH, H+, and O2, whereas its 3 products are , NADP+, and H2O. (en)
- La colestanotriolo 26-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 5β-colestan-3α,7α,12α-triolo + NADPH + H+ + O2 ⇄ (25R)-5β-colestan-3α,7α,12α,26-tetraolo + NADP+ + H2O (it)
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