Trioxsalen (trimethylpsoralen, trioxysalen (INN) or Trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage. The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA

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dbo:abstract
  • Trioxsalen ist eine chemische Verbindung aus der Gruppe der Furocumarine und Psoralenderivate. (de)
  • Il trimetilpsoralene, o trioxsalene, è una sostanza organica naturale appartenente alla famiglia delle furanocumarine, prodotta come difesa da alcune piante, principalmente dalla . (it)
  • Trioxsalen (trimethylpsoralen, trioxysalen (INN) or Trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage. The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair. (en)
  • Trioxsaleno é um fármaco que ativa a . Utilizado para a repigmentação em casos de vitiligo, também é utilizada como coadjuvante no tratamento da psoríase. De mecanismo de ação ainda não elucidado, necessita de estimulo solar para formação de melanina. (pt)
dbo:iupacName
  • 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one (en)
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  • Trioxsalen.png (en)
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  • Trioxsalen ist eine chemische Verbindung aus der Gruppe der Furocumarine und Psoralenderivate. (de)
  • Il trimetilpsoralene, o trioxsalene, è una sostanza organica naturale appartenente alla famiglia delle furanocumarine, prodotta come difesa da alcune piante, principalmente dalla . (it)
  • Trioxsaleno é um fármaco que ativa a . Utilizado para a repigmentação em casos de vitiligo, também é utilizada como coadjuvante no tratamento da psoríase. De mecanismo de ação ainda não elucidado, necessita de estimulo solar para formação de melanina. (pt)
  • Trioxsalen (trimethylpsoralen, trioxysalen (INN) or Trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage. The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA (en)
rdfs:label
  • Trioxsalen (de)
  • Trioxsalen (en)
  • Trimetilpsoralene (it)
  • Trioxsaleno (pt)
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