dbo:abstract
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- Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness. (en)
- Pramocaïne (ook wel pramoxine genoemd) is een geneesmiddel, gebruikt als lokaal anestheticum. Het wordt alleen toegepast in verdovende crèmes.Binnen lokale anesthetica worden amidetype en estertype middelen onderscheiden. Pramocaïne valt in geen van beide klassen. (nl)
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- Depends on country, some formulations OTC others Rx only (en)
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- Topical, rectal, Vaginal (en)
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- DQKXQSGTHWVTAD-UHFFFAOYSA-N (en)
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- Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness. (en)
- Pramocaïne (ook wel pramoxine genoemd) is een geneesmiddel, gebruikt als lokaal anestheticum. Het wordt alleen toegepast in verdovende crèmes.Binnen lokale anesthetica worden amidetype en estertype middelen onderscheiden. Pramocaïne valt in geen van beide klassen. (nl)
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rdfs:label
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- Pramocaine (en)
- Pramocaïne (nl)
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