Ponchatoula Creek is a 26.1-mile-long (42.0 km) tributary of the Natalbany River in Tangipahoa Parish, Louisiana. The two waterways join where a section of the Natalbany forms the boundary between Tangipahoa Parish and Livingston Parish. Ponchatoula Creek originates west of Old US Highway 51, 1 mile (1.6 km) north of Independence. The creek is entirely within Tangipahoa Parish.