About: Pavinetant

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Pavinetant (INN, USAN; developmental code names MLE-4901, AZD-4901, AZ-12472520, AZD-2624), is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which was under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS). It was also under investigation for the treatment of schizophrenia, but development was discontinued for this indication due to lack of effectiveness. In November 2017, development of the medication for hot flashes and PCOS was also terminated after its developer assessed the clinical risks and benefits.

Property	Value
dbo:abstract	Pavinetant (INN, USAN; developmental code names MLE-4901, AZD-4901, AZ-12472520, AZD-2624), is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which was under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS). It was also under investigation for the treatment of schizophrenia, but development was discontinued for this indication due to lack of effectiveness. In November 2017, development of the medication for hot flashes and PCOS was also terminated after its developer assessed the clinical risks and benefits. (en)
dbo:casNumber	941690-55-7
dbo:chEBI	140478
dbo:chEMBL	3545233
dbo:fdaUniiCode	3U471ZVC5K
dbo:kegg	D11345
dbo:pubchem	23649245
dbo:thumbnail	wiki-commons:Special:FilePath/MLE-4901.svg?width=300
dbo:wikiPageExternalLink	http://adisinsight.springer.com/drugs/800038259
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dbo:wikiPageLength	4182 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1045199915 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Schizophrenia dbc:NK3_receptor_antagonists dbc:Abandoned_drugs dbr:Oral_administration dbr:Hot_flash dbr:Receptor_antagonist dbc:Carboxamides dbc:Quinolines dbr:AstraZeneca dbc:Sulfonamides dbr:Binding_selectivity dbr:Polycystic_ovary_syndrome dbr:Tachykinin_receptor_3 dbr:Small-molecule
dbp:c	26 (xsd:integer)
dbp:casNumber	941690 (xsd:integer)
dbp:chebi	140478 (xsd:integer)
dbp:chembl	3545233 (xsd:integer)
dbp:chemspiderid	28189763 (xsd:integer)
dbp:h	25 (xsd:integer)
dbp:iupacName	3 (xsd:integer)
dbp:kegg	D11345 (en)
dbp:n	3 (xsd:integer)
dbp:o	3 (xsd:integer)
dbp:pubchem	23649245 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:s	1 (xsd:integer)
dbp:smiles	CC[C@@H]NCC2=CNSC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	QYTBBBAHNIWFOD-NRFANRHFSA-N (en)
dbp:synonyms	MLE-4901; AZD-4901; AZD-2624; AZ-12472520 (en)
dbp:unii	3 (xsd:integer)
dbp:width	225 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Genito-urinary-drug-stub dbt:Nervous-system-drug-stub dbt:Reflist dbt:Abbrlink dbt:Neurokinin_receptor_modulators
dcterms:subject	dbc:NK3_receptor_antagonists dbc:Abandoned_drugs dbc:Carboxamides dbc:Quinolines dbc:Sulfonamides
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Pavinetant (INN, USAN; developmental code names MLE-4901, AZD-4901, AZ-12472520, AZD-2624), is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which was under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS). It was also under investigation for the treatment of schizophrenia, but development was discontinued for this indication due to lack of effectiveness. In November 2017, development of the medication for hot flashes and PCOS was also terminated after its developer assessed the clinical risks and benefits. (en)
rdfs:label	Pavinetant (en)
owl:sameAs	wikidata:Pavinetant https://global.dbpedia.org/id/2Y36R
prov:wasDerivedFrom	wikipedia-en:Pavinetant?oldid=1045199915&ns=0
foaf:depiction	wiki-commons:Special:FilePath/MLE-4901.svg
foaf:isPrimaryTopicOf	wikipedia-en:Pavinetant
is dbo:wikiPageRedirects of	dbr:MLE-4901 dbr:AZ-12472520 dbr:AZ12472520 dbr:AZD-2624 dbr:AZD-4901 dbr:AZD2624 dbr:AZD4901 dbr:AZD_2624 dbr:AZD_4901 dbr:AZ_12472520 dbr:MLE4901 dbr:MLE_4901
is dbo:wikiPageWikiLink of	dbr:MLE-4901 dbr:Tachykinin_receptor_3 dbr:AZ-12472520 dbr:AZ12472520 dbr:AZD-2624 dbr:AZD-4901 dbr:AZD2624 dbr:AZD4901 dbr:AZD_2624 dbr:AZD_4901 dbr:AZ_12472520 dbr:MLE4901 dbr:MLE_4901
is foaf:primaryTopic of	wikipedia-en:Pavinetant