| dbo:abstract
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- The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase. In addition, PHLPP dephosphorylates conventional and novel members of the protein kinase C family at their hydrophobic motifs, corresponding to Ser-660 in PKCβII. (en)
- Les PHLPP (de l'anglais : PH domain and Leucine rich repeat Protein Phosphatase) sont une famille de protéines de type phosphatase, permettant l'inactivation des protéine Akt. Cette famille est composée de trois isoformes : PHLPP1α, PHLPP1β (issu du même gène PHLPP1 mais épissée différemment) et PHLPP2. (fr)
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| dbo:arm
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| dbo:chromosome
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| dbo:ecNumber
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| dbo:entrezgene
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| dbo:hgncid
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| dbo:omim
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- 609396 (xsd:integer)
- 611066 (xsd:integer)
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| dbo:refseq
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| dbo:symbol
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- PHLPP
- PHLPP1, PLEKHE1
- PHLPP2
- PHLPPL
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| dbo:uniprot
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| dbo:wikiPageID
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| dbo:wikiPageLength
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- 12054 (xsd:nonNegativeInteger)
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| dbo:wikiPageRevisionID
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| dbo:wikiPageWikiLink
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| dbp:altsymbols
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- PHLPP2 (en)
- PHLPP1, PLEKHE1 (en)
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| dbp:arm
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| dbp:band
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- 21.320000 (xsd:double)
- 22.200000 (xsd:double)
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| dbp:chromosome
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- 16 (xsd:integer)
- 18 (xsd:integer)
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| dbp:ecnumber
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| dbp:entrezgene
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- 23035 (xsd:integer)
- 23239 (xsd:integer)
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| dbp:hgncid
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- 20610 (xsd:integer)
- 29149 (xsd:integer)
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| dbp:name
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| dbp:omim
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- 609396 (xsd:integer)
- 611066 (xsd:integer)
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| dbp:refseq
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- NM_015020 (en)
- XM_166290 (en)
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| dbp:symbol
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| dbp:uniprot
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| dbp:wikiPageUsesTemplate
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| dcterms:subject
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| gold:hypernym
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| rdf:type
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| rdfs:comment
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- Les PHLPP (de l'anglais : PH domain and Leucine rich repeat Protein Phosphatase) sont une famille de protéines de type phosphatase, permettant l'inactivation des protéine Akt. Cette famille est composée de trois isoformes : PHLPP1α, PHLPP1β (issu du même gène PHLPP1 mais épissée différemment) et PHLPP2. (fr)
- The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase. (en)
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| prov:wasDerivedFrom
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| foaf:isPrimaryTopicOf
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| foaf:name
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- PH domain and leucine rich repeat protein phosphatase-like (en)
- PH domain and leucine-rich repeat protein phosphatase (en)
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| is dbo:wikiPageRedirects
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| is dbo:wikiPageWikiLink
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| is foaf:primaryTopic
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