The Nestorian Schism (431), in church history, involved a split between the Christian churches of Sassanid Persia, which affiliated with Nestorius, and churches that rejected him. The schism rose out of a Christological dispute, notably involving Cyril (Patriarch of Alexandria) and Nestorius (Patriarch of Constantinople). The First Council of Ephesus in 431 and the Council of Chalcedon in 451 condemned Nestorius and his doctrine, which emphasized the radical distinctness between Christ's human and divine natures.
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