Nathaniel Stone Simpkins (Jan. 8, 1796 – June 18, 1887) was a bookseller, publisher, and legislator in Massachusetts in the 19th century. He ran a bookshop and circulating library in Boston ca.1820-1830. "In 1835 he established the Barnstable Journal [of Barnstable, Massachusetts], and in 1856 he established the Yarmouth Register" of Yarmouth, Massachusetts. Simpkins served as a "Representative to the General Court of Mass. in 1836, 1850 and 1851."