About: Moniliformin

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Moniliformin is an unusual mycotoxin, a feed contaminant that is lethal to fowl, especially ducklings. Moniliformin is formed in many cereals by a number of Fusarium species that include Fusarium moniliforme, Fusarium avenaceum, Fusarium subglutinans, Fusarium proliferatum, Fusarium fujikuroi and others. It is mainly cardiotoxic and causes ventricular hypertrophy. Moniliformin actually causes competitive inhibition of the activity of pyruvate dehydrogenase complex of respiratory reaction, which prevents pyruvic acid, product of glycolysis, to convert to acetyl CoA. Ultrastructural examination of right ventricular wall of 9 month old female mink (Mustela vison) fed acute doses of moniliformin (2.2 and 2.8 mg/kg diet) and sub-acute doses (1.5 to 3.2 mg/kg diet) reveals significant damage to

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dbo:abstract
  • Semiquadratsäure, auch Moniliformin genannt, ist, wie die verwandte Quadratsäure, ein Abkömmling des Cyclobutens. (de)
  • Moniliformin is an unusual mycotoxin, a feed contaminant that is lethal to fowl, especially ducklings. Moniliformin is formed in many cereals by a number of Fusarium species that include Fusarium moniliforme, Fusarium avenaceum, Fusarium subglutinans, Fusarium proliferatum, Fusarium fujikuroi and others. It is mainly cardiotoxic and causes ventricular hypertrophy. Moniliformin actually causes competitive inhibition of the activity of pyruvate dehydrogenase complex of respiratory reaction, which prevents pyruvic acid, product of glycolysis, to convert to acetyl CoA. Ultrastructural examination of right ventricular wall of 9 month old female mink (Mustela vison) fed acute doses of moniliformin (2.2 and 2.8 mg/kg diet) and sub-acute doses (1.5 to 3.2 mg/kg diet) reveals significant damage to myofiber, mitochondria, Z and M lines and sarcoplasmic reticulum as well as increased extracellular collagen deposition. Mink is considered most sensitive mammals to the toxicity of moniliformin.Chemically speaking, it is the sodium salt of deoxysquaric acid (en)
  • Moniliformina (MON) – organiczny związek chemiczny, mykotoksyna będąca toksycznym metabolitem wtórym grzybów z rodzaju Fusarium. (pl)
  • 半方酸是一种有机化合物,化学式为C4H2O3,它在自然界以钠盐或钾盐的形式存在于鐮孢菌屬一些生物的次级代谢产物中。 它是在自然界中存在的最强的有机酸(pKa=0.88),水貂对其毒性最为敏感。 (zh)
dbo:alternativeName
  • Semisquaric acid (en)
dbo:iupacName
  • 3-hydroxycyclobut-3-ene-1,2-dione (en)
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  • 18711086 (xsd:integer)
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  • 3461 (xsd:nonNegativeInteger)
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  • 1061216614 (xsd:integer)
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dbp:imagefile
  • Moniliformin sodium.png (en)
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  • 120 (xsd:integer)
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  • 3 (xsd:integer)
dbp:othernames
  • Semisquaric acid (en)
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  • 412682209 (xsd:integer)
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rdfs:comment
  • Semiquadratsäure, auch Moniliformin genannt, ist, wie die verwandte Quadratsäure, ein Abkömmling des Cyclobutens. (de)
  • Moniliformina (MON) – organiczny związek chemiczny, mykotoksyna będąca toksycznym metabolitem wtórym grzybów z rodzaju Fusarium. (pl)
  • 半方酸是一种有机化合物,化学式为C4H2O3,它在自然界以钠盐或钾盐的形式存在于鐮孢菌屬一些生物的次级代谢产物中。 它是在自然界中存在的最强的有机酸(pKa=0.88),水貂对其毒性最为敏感。 (zh)
  • Moniliformin is an unusual mycotoxin, a feed contaminant that is lethal to fowl, especially ducklings. Moniliformin is formed in many cereals by a number of Fusarium species that include Fusarium moniliforme, Fusarium avenaceum, Fusarium subglutinans, Fusarium proliferatum, Fusarium fujikuroi and others. It is mainly cardiotoxic and causes ventricular hypertrophy. Moniliformin actually causes competitive inhibition of the activity of pyruvate dehydrogenase complex of respiratory reaction, which prevents pyruvic acid, product of glycolysis, to convert to acetyl CoA. Ultrastructural examination of right ventricular wall of 9 month old female mink (Mustela vison) fed acute doses of moniliformin (2.2 and 2.8 mg/kg diet) and sub-acute doses (1.5 to 3.2 mg/kg diet) reveals significant damage to (en)
rdfs:label
  • Semiquadratsäure (de)
  • Moniliformin (en)
  • Moniliformina (pl)
  • 半方酸 (zh)
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