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The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused by stressors such as increased temperatures, oxidative stress, and heavy metals. In a normal cell, proteostasis (protein homeostasis) must be maintained because proteins are the main functional units of the cell. Many proteins take on a defined configuration in a process known as protein folding in order to perform their biological functions. If these structures are altered, critical processes could be affected, leading to cell damage or death. The heat shock response can be employed under stress to induce the expression of heat shock proteins (HSP), many of which are molecular chaperones, that help prevent or reverse protein misfolding

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  • En biologia cel·lular, un xoc tèrmic és un estrès que sofreix un organisme viu després d’un augment de la seva temperatura per sobre d’un cert valor. Condueix en particular a l'activació de proteïnes de xoc tèrmic. El xoc tèrmic pot provocar lesions cel·lulars i la mort de l’organisme. En tecnologia alimentària el principi del xoc tèrmic s’utilitza especialment per a la reducció de la càrrega d'agents potencialment patògens d'alguns aliments com ara la pasteurització o la uperització de la llet mitjançant processos com l'UHT. (ca)
  • Als Hitzeschock wird in der Zellbiologie ein Zustand der Zelle bei Temperaturextremen, toxischen Chemikalien oder starker Bestrahlung bezeichnet; gemeinsam ist diesen Bedingungen, dass die Zellproteine drohen, zu denaturieren. Die Zelle reagiert mit einer Art Notfallprogramm, zu dem u. a. die Expression sogenannter Hitzeschockproteine gehört. (de)
  • Varmegŝoko estas termino el la ĉelbiologio kaj priskribas la staton de ĉeloj ĉe temperaturekstremoj, toksaj kemiaĵoj kaj forta priradiado. La ĉelproteinoj minacas denaturigi. La ĉelo reagas per produktado de tiel nomataj . (eo)
  • The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused by stressors such as increased temperatures, oxidative stress, and heavy metals. In a normal cell, proteostasis (protein homeostasis) must be maintained because proteins are the main functional units of the cell. Many proteins take on a defined configuration in a process known as protein folding in order to perform their biological functions. If these structures are altered, critical processes could be affected, leading to cell damage or death. The heat shock response can be employed under stress to induce the expression of heat shock proteins (HSP), many of which are molecular chaperones, that help prevent or reverse protein misfolding and provide an environment for proper folding. Protein folding is already challenging due to the crowded intracellular space where aberrant interactions can arise; it becomes more difficult when environmental stressors can denature proteins and cause even more non-native folding to occur. If the work by molecular chaperones is not enough to prevent incorrect folding, the protein may be degraded by the proteasome or autophagy to remove any potentially toxic aggregates. Misfolded proteins, if left unchecked, can lead to aggregation that prevents the protein from moving into its proper conformation and eventually leads to plaque formation, which may be seen in various diseases. Heat shock proteins induced by the HSR can help prevent protein aggregation that is associated with common neurodegenerative diseases such as Alzheimer's, Huntington's, or Parkinson's disease. (en)
  • En médecine, un choc thermique est un stress subi par un organisme vivant à la suite d'une élévation de sa température au-delà d'une certaine valeur. Il conduit notamment à l'activation des protéines de choc thermique. Un choc thermique peut entraîner la mort de l'organisme. Le principe du choc thermique est notamment utilisé pour la stérilisation UHT du lait. (fr)
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  • En biologia cel·lular, un xoc tèrmic és un estrès que sofreix un organisme viu després d’un augment de la seva temperatura per sobre d’un cert valor. Condueix en particular a l'activació de proteïnes de xoc tèrmic. El xoc tèrmic pot provocar lesions cel·lulars i la mort de l’organisme. En tecnologia alimentària el principi del xoc tèrmic s’utilitza especialment per a la reducció de la càrrega d'agents potencialment patògens d'alguns aliments com ara la pasteurització o la uperització de la llet mitjançant processos com l'UHT. (ca)
  • Als Hitzeschock wird in der Zellbiologie ein Zustand der Zelle bei Temperaturextremen, toxischen Chemikalien oder starker Bestrahlung bezeichnet; gemeinsam ist diesen Bedingungen, dass die Zellproteine drohen, zu denaturieren. Die Zelle reagiert mit einer Art Notfallprogramm, zu dem u. a. die Expression sogenannter Hitzeschockproteine gehört. (de)
  • Varmegŝoko estas termino el la ĉelbiologio kaj priskribas la staton de ĉeloj ĉe temperaturekstremoj, toksaj kemiaĵoj kaj forta priradiado. La ĉelproteinoj minacas denaturigi. La ĉelo reagas per produktado de tiel nomataj . (eo)
  • En médecine, un choc thermique est un stress subi par un organisme vivant à la suite d'une élévation de sa température au-delà d'une certaine valeur. Il conduit notamment à l'activation des protéines de choc thermique. Un choc thermique peut entraîner la mort de l'organisme. Le principe du choc thermique est notamment utilisé pour la stérilisation UHT du lait. (fr)
  • The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused by stressors such as increased temperatures, oxidative stress, and heavy metals. In a normal cell, proteostasis (protein homeostasis) must be maintained because proteins are the main functional units of the cell. Many proteins take on a defined configuration in a process known as protein folding in order to perform their biological functions. If these structures are altered, critical processes could be affected, leading to cell damage or death. The heat shock response can be employed under stress to induce the expression of heat shock proteins (HSP), many of which are molecular chaperones, that help prevent or reverse protein misfolding (en)
rdfs:label
  • Xoc tèrmic (biologia) (ca)
  • Hitzeschock (de)
  • Varmegŝoko (eo)
  • Heat shock response (en)
  • Choc thermique (médecine) (fr)
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