About: CD32

An Entity of Type: Biomolecule, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. CD32 can be found on the surface of a variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has two major functions: cellular response regulation, and the uptake of immune complexes.

Property Value
dbo:abstract
  • CD32 هوَ بروتين يُشَفر بواسطة جين CD32 في الإنسان. (ar)
  • CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. CD32 can be found on the surface of a variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has two major functions: cellular response regulation, and the uptake of immune complexes. Cellular responses regulated by CD32 include phagocytosis, cytokine stimulation, and endocytic transport. Dysregulated CD32 is associated with different forms of autoimmunity, including systemic lupus erythematosus. In humans, there are three major CD32 subtypes: CD32A, CD32B, and CD32C. While CD32A and CD32C are involved in activating cellular responses, CD32B is inhibitory. (en)
  • Il CD32 è una glicoproteina di membrana presente sui linfociti B e sui macrofagi. Il suo nome FCγRII è indicativo della sua funzione ovvero recettore per la parte costante delle immunoglobuline di tipo γ con affinità intermedia (mentre ha affinità alta e bassa). (it)
dbo:arm
  • q
dbo:band
  • 23
dbo:chromosome
  • 1
dbo:entrezgene
  • 2212
  • 9103
  • 2213
dbo:hgncid
  • 15626
  • 3616
  • 3618
dbo:omim
  • 146790 (xsd:integer)
  • 604590 (xsd:integer)
dbo:refseq
  • NM_004001
  • NM_021642
  • NM_201563
dbo:symbol
  • FCG2, FCGR2
  • FCG2, FCGR2A1, FCGR2
  • FCGR2A
  • FCGR2B
  • FCGR2C
dbo:thumbnail
dbo:uniprot
  • P12318
  • P31994
  • P31995
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  • 245408 (xsd:integer)
dbo:wikiPageLength
  • 10994 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 993665808 (xsd:integer)
dbo:wikiPageWikiLink
dbp:altsymbols
  • FCG2, FCGR2 (en)
  • FCG2, FCGR2A1, FCGR2 (en)
dbp:arm
  • q (en)
dbp:band
  • 23 (xsd:integer)
dbp:caption
  • Crystal structure of the human fcgamma-receptor IIb ectodomain . (en)
dbp:chromosome
  • 1 (xsd:integer)
dbp:entrezgene
  • 2212 (xsd:integer)
  • 2213 (xsd:integer)
  • 9103 (xsd:integer)
dbp:hgncid
  • 3616 (xsd:integer)
  • 3618 (xsd:integer)
  • 15626 (xsd:integer)
dbp:name
dbp:omim
  • 146790 (xsd:integer)
  • 604590 (xsd:integer)
dbp:refseq
  • NM_004001 (en)
  • NM_021642 (en)
  • NM_201563 (en)
dbp:symbol
dbp:uniprot
  • P12318 (en)
  • P31994 (en)
  • P31995 (en)
dbp:wikiPageUsesTemplate
dct:subject
gold:hypernym
rdf:type
rdfs:comment
  • CD32 هوَ بروتين يُشَفر بواسطة جين CD32 في الإنسان. (ar)
  • Il CD32 è una glicoproteina di membrana presente sui linfociti B e sui macrofagi. Il suo nome FCγRII è indicativo della sua funzione ovvero recettore per la parte costante delle immunoglobuline di tipo γ con affinità intermedia (mentre ha affinità alta e bassa). (it)
  • CD32 (cluster of differentiation 32), also known as FcγRII or FCGR2, is a surface receptor glycoprotein belonging to the Ig gene superfamily. CD32 can be found on the surface of a variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has two major functions: cellular response regulation, and the uptake of immune complexes. (en)
rdfs:label
  • CD32 (en)
  • CD32 (ar)
  • CD32 (proteina) (it)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
foaf:name
  • Fc fragment of IgG, low affinity IIc, receptor for (CD32) (en)
  • Fc fragment of IgG, low affinity IIb, receptor (CD32) (en)
  • Fc fragment of IgG, low affinity IIa, receptor (CD32) (en)
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