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Bovhyaluronidase azoximer, sold under the brand name Longidaze, is a conjugate of proteolytic enzyme hyaluronidase with high- molecular weight copolymer that forms a component of combination therapy regimens for treatment and prevention of diseases associated with connective tissue hyperplasia.The most frequently observed adverse reactions seen with bovhyaluronidase azoximer include pain at site of injection and injection site reaction n such as skin redness, itching and oedema. All local reactions resolve themselves in 48 – 72 hours.