About: Anode break excitation

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Anode break excitation (ABE) is an electrophysiological phenomenon whereby a neuron fires action potentials in response to termination of a hyperpolarizing current. When a hyperpolarizing current is applied across a membrane, the electrical potential across the membrane falls (becomes negative of the resting potential); this fall is followed by a drop in the threshold required for action potential (since the threshold is directly linked to the potential across the membrane - they rise and fall together).

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  • Anode break excitation (ABE) is an electrophysiological phenomenon whereby a neuron fires action potentials in response to termination of a hyperpolarizing current. When a hyperpolarizing current is applied across a membrane, the electrical potential across the membrane falls (becomes negative of the resting potential); this fall is followed by a drop in the threshold required for action potential (since the threshold is directly linked to the potential across the membrane - they rise and fall together). ABE arises after the hyperpolarizing current is terminated: the potential across the cell rises rapidly with the absence of hyperpolarizing stimulus, but the action potential threshold stays at its lowered value. As a result, the potential is suprathreshold: sufficient to cause an action potential within the cell. (en)
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  • Anode break excitation (ABE) is an electrophysiological phenomenon whereby a neuron fires action potentials in response to termination of a hyperpolarizing current. When a hyperpolarizing current is applied across a membrane, the electrical potential across the membrane falls (becomes negative of the resting potential); this fall is followed by a drop in the threshold required for action potential (since the threshold is directly linked to the potential across the membrane - they rise and fall together). (en)
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  • Anode break excitation (en)
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