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A xanthonoid is a chemical natural phenolic compound formed from the xanthone backbone. Many members of the Clusiaceae contain xanthonoids. Xanthonoid biosynthesis in cell cultures of Hypericum androsaemum involves the presence of a benzophenone synthase condensing a molecule of benzoyl-CoA with three malonyl-CoA yielding to . This intermediate is subsequently converted by a , a cytochrome P450 monooxygenase, leading to the formation of . Cytotoxic xanthones can be isolated from the dry latex of Garcinia hanburyi (gamboge tree).

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