St. Regis Mohawk Reservation is a Mohawk Indian reservation of the federally recognized tribe the St. Regis Mohawk Tribe, located in Franklin County, New York, United States. It is also known by its Mohawk name, Akwesasne. The population was 3,288 at the 2010 census. The reservation is adjacent to the Akwesasne reserve in Ontario and Quebec across the St. Lawrence River. The Mohawk consider the entire community to be one unit and have the right to travel freely across the international border.