Sir John Duke, 2nd Baronet (3 January 1632 - July 1705 ) was an English politician who sat in the House of Commons variously between 1679 and 1698. Duke was the son of Sir Edward Duke, 1st Baronet of Benhall, Suffolk and his wife Ellenor Panton, daughter of John Panton of Westminster and of Brunslip, Denbighshire. His father had been MP for Orford. He was educated at Emmanuel College, Cambridge, and travelled abroad in 1657. He was commissioner for assessment for Suffolk from 1661 to 1680 and became a Deputy Lieutenant and J.P. for Suffolk in 1671. He succeeded to the baronetcy on the death of his father in 1673. He was commissioner for recusants in 1675 and mayor of Orford from 1677 to 1678.