Sir Charles Hussey (1626 – 2 December 1664) was an English politician who sat in the House of Commons in two periods between 1656 and 1664. Hussey was the son of Sir Edward Hussey, 1st Baronet of Honington and his wife Elizabeth Anton, daughter of George Anton of Lincoln. He was baptised on 30 October 1626. In 1646 he was admitted at Gray's Inn. His father died in 1648, but the baronetcy went to Hussey's nephew Thomas, son of his deceased brother Thomas. He was commissioner for assessment for Lincolnshire 1652. In 1656, he was elected Member of Parliament for Lincolnshire in the Second Protectorate Parliament. He was commissioner for assessment for Lincolnshire in 1657 and commissioner for militia for Lincolnshire in 1659.