Otto Herbert Wolff, CBE, FRCP (born 10 January 1920 in Hamburg, died 27 April 2010) was a German born medical scientist, paediatrician and was the Nuffield Professor of Child Health at Great Ormond Street Hospital. Wolff was notable for being one of the first paediatricians in Britain to set up a clinic for obese children. Later research into plasma lipids with pioneered the techniques of . He later conducted research into the role of lipid disturbance in childhood as a precursor of coronary artery disease and his recognition in 1960 of the rare condition of abetalipoproteinaemia. Wolff was also co-discoverer of the Edwards syndrome in abnormal chromosomes.