Orangeburg, also known as The Garden City, is the principal city in and the county seat of Orangeburg County, South Carolina, United States. The population of the city was 13,964 according to the 2010 United States Census and declined to 12,704 in the 2020 census. The city is located 37 miles southeast of Columbia, on the north fork of the Edisto River. Two historically black institutions of higher education are located in Orangeburg: Claflin University (a liberal arts college) and South Carolina State University (a public university).