Moccasin Gap, also known as Big Moccasin Gap, is a pass in Clinch Mountain, a long ridge within the Appalachian Mountains, at Gate City, Virginia.This gap has a long history as a passageway through the mountain. It was used by the Cherokee and Shawnee, and was the first gap through which the Daniel Boone Wilderness Road passed on its way to the better-known Cumberland Gap and Kentucky. Today it serves as a primary commercial route for industry, retail, and tourism businesses.