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The Santiago lava lizard (Microlophus jacobi) is a species of lava lizard in the family Tropiduridae. They are endemic to the Galapagos islands of Santiago, Bartolomé, Rábida and a few islets. They are also the only lava lizards present on these islands. This species was formerly considered a subpopulation of the Galápagos lava lizard, but is now widely considered as a distinct species.