Mary-Anne Plaatjies van Huffel (15 December 1959 – 19 May 2020) was a South African pastor and academic. She was the first female minister to be ordained by a Dutch Reformed Church in Southern Africa. Plaatjies van Huffel was educated at the Bergriver High School in Wellington, and studied at University of the Western Cape, the University of South Africa (UNISA) and Pretoria University. She was the holder of two doctorates in Theology, one from UNISA (2003 Thesis on: Women in the theological anthropology of the Afrikaans Reformed Churches) and one from University of Pretoria (2009 Thesis on: Doleantie Church Polity and the church polity development of the mission churches in South Africa.