The Main-Neckar Railway (German: Main-Neckar–Eisenbahn, MNE) is a main line railway west of the Odenwald in the Upper Rhine Plain of Germany that connects Frankfurt am Main to Heidelberg via Darmstadt, Bensheim and Weinheim. It was opened in 1846 and is one of the oldest railways in Germany. The railway line is part of the networks served by the Rhein-Main-Verkehrsverbund and Verkehrsverbund Rhein-Neckar.