The twenty-first series of Made in Chelsea, a British structured-reality television programme began airing on 29 March 2021, and concluded after twelve episodes on 14 June. Due to the COVID-19 pandemic, like the previous series it was announced that the cast would be following government guidelines whilst filming this series, with some of the cast moving into country houses located in the Cotswolds and Suffolk where they were quarantined together. The series ended with an episode back in its usual location in Chelsea.