Louisiana Highway 16 (LA 16) is a state highway located in southeastern Louisiana. It runs 110.27 miles (177.46 km) in a general east–west direction from LA 22 south of French Settlement to LA 21 in Sun. LA 16 was designated in the 1955 Louisiana Highway renumbering, stitched together from six shorter former routes, including south of Denham Springs; between Watson and Amite City; and between Amite City and Franklinton.