The Layton Building is a historic commercial building at 1110 Mill Street in downtown Yellville, Arkansas. Built in 1906, this rusticated stone two-story building is one of the largest in Marion County. It has five irregularly-sized bays on the first floor and six on the second. The entrances to the storefronts are set inward at a 45 degree angle. There are decorative metal cornices between the floors and at the roof line. The building's original commercial tenants were the Bank of Yellville and the Layton Department Store; the bank's vault is still in the building.