The Killough massacre is believed to have been both the largest and last Native American attack on white settlers in East Texas. The massacre took place on October 5, 1838, near Larissa, Texas, in the northwestern part of Cherokee County. There were eighteen victims, including Isaac Killough, Sr., and his extended family (viz. the families of four sons and two daughters). They had immigrated to the Republic of Texas from Talladega County, Alabama, in 1837.