Isabella (Armenian: Զապել; 27 January 1216/ 25 January 1217 – 23 January 1252), also Isabel or Zabel, was queen regnant of Armenian Cilicia from 1219 until her death in 1252. She was proclaimed queen under the regency of Adam of Baghras. After he was assassinated, Constantine of Baberon (of the Hethumid family) was nominated as guardian. At this juncture, Raymond-Roupen, grandson of Roupen III (the elder brother of Isabella’s father, King Leo I), attempted to claim to throne of Cilicia for himself, but he was defeated, captured, and executed.