The George W. and Nancy B. Van Dusen House is a mansion in the Stevens Square neighborhood of Minneapolis, Minnesota, United States. The owner, George Washington Van Dusen, was an entrepreneur who founded Minnesota's first and most prosperous grain processing and distribution firm in 1883. In 1891, he hired the firm of Orff and Joralemon to build a 12,000-square-foot (1,100 m2) mansion on what was then the southwestern edge of Minneapolis. His house reflects the prosperity achieved by business owners who were making money in the flourishing grain, railroad, and lumber industries in the late 19th century. The mansion was listed on the National Register of Historic Places in 1995.