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Georg Ledderhose (15 December 1855, Bockenheim, , Germany – 1 February 1925, Munich, Germany) was a German surgeon. Ledderhose studied in Strasbourg under Georg Albert Lücke (1829–1894), receiving his medical doctorate in 1880 and later working in Strasbourg hospital as a surgeon. He became Professor for Surgery in Strasbourg in 1891. He later worked in Munich, where he became honorary professor. Ledderhose was the first to describe the condition of plantar fibromatosis in 1894, which was later known as Ledderhose's disease.