Peromyscus maniculatus is a rodent native to eastern North America. It is most commonly called the eastern deer mouse; when formerly grouped with the western deer mouse (P. sonoriensis), it was referred to as the North American deermouse and is fairly widespread across most of North America east of the Mississippi River, with the major exception being the lowland southeastern United States. Like other Peromyscus species, it can be a vector and carrier of emerging infectious diseases such as hantaviruses and Lyme disease. It is closely related to Peromyscus leucopus, the white-footed mouse.