Carol Denison Frost (born 23 May 1957) is an American isotope geologist, petrologist and professor. Her primary research focuses on the evolution of the continental crust and granite petrogenesis. She has spent over thirty-five years investigating the geologic history of the Wyoming Province and the formation and geochemical classification of granite. Other contributions include isotopic fingerprinting of natural waters, including water associated with energy production. She served as Director of the Earth Sciences Division, National Science Foundation, from December 2014 to January 2018.