Caldwell Street Historic District is a national historic district located at Newberry, Newberry County, South Carolina. The district encompasses 10 contributing buildings and 1 contributing site in Newberry. The district includes eight upper class residences, two churches, and a cemetery. The buildings reflect popular architectural styles from the late-19th and early-20th century including Victorian, Queen Anne, Tudor Revival, Gothic Revival, and Neoclassical. It was listed on the National Register of Historic Places in 1980.