COVID-19 vaccination in Botswana is an ongoing immunisation campaign against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), in response to the ongoing pandemic in the country. Mass vaccination started on 26 March 2021, initially with AstraZeneca's Covishield vaccine. As of 7 June 2021, Botswana has administered 150,019 doses.