Blood and Guts in High School is a novel by Kathy Acker. It was written in the late 1970s and copyrighted in 1978. It traveled a complex and circuitous route to publication, before being officially released in 1984. It remains Acker's most popular and best-selling book. The novel is also considered a metafictional text, which is aware of its status as a fictional piece. The novel explores but simultaneously deconstructs the American politics of the time it was written and intercontinental history tying into the novel's subject of human trafficking, while being interspersed with sections of sexually detailed drawings, , symbolism and non-linear writing.