Antonino (born Antonio) Spatafora (died 22 June 1613) was an Italian painter, architect, sculptor and cartographer. Born in Palermo, Sicily in the mid 16th century, he is notable as one of the foremost artists of Sicilian Mannerism, with pupils including Vincenzo La Barbera. Several documents refer to him as a sculptor, though none of his sculptures survive. He died in Termini Imerese, Sicily.