Anne de Pisseleu d'Heilly, Duchess of Étampes, (1508 – 1580) was chief mistress of Francis I of France. She became Francis' mistress following his return from captivity in 1526. Anne enriched her family and friends through her courtly influence and after Francis' death was banished from court and temporarily imprisoned in her husband's castle. She would spend her later years ensuring the fortune of her family. Anne died in 1580.