Amorpha-4,11-diene 12-monooxygenase (EC 1.14.13.158, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following chemical reaction amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ + 3 NADP+ + 4 H2O (overall reaction)(1a) amorpha-4,11-diene + O2 + NADPH + H+ + NADP+ + H2O(1b) artemisinic alcohol + O2 + NADPH + H+ + NADP+ + 2 H2O(1c) artemisinic aldehyde + O2 + NADPH + H+ + NADP+ + H2O Amorpha-4,11-diene 12-monooxygenase is a heme-thiolate protein (P-450)