A Treatise on the Binomial Theorem is a fictional work of mathematics by the young Professor James Moriarty, the criminal mastermind and archenemy of the detective Sherlock Holmes in the fiction of Arthur Conan Doyle. The actual title of the treatise is never given in the stories; Holmes simply refers to "a treatise upon the Binomial Theorem". The treatise is mentioned in the 1893 short story "The Final Problem", when Holmes, speaking of Professor Moriarty, states: — Sherlock Holmes, "The Final Problem"