The 2021 Trofeo Laigueglia was a one-day road cycling race that took place on 2 March 2021 in and around Laigueglia, Liguria, on the northwestern coast of Italy. It was the 58th edition of the Trofeo Laigueglia and was rated as a 1.Pro event as part of the 2021 UCI Europe Tour and the 2021 UCI ProSeries. The race covered 202 kilometres (126 mi) and finished off with four laps of a finishing circuit that was 11 kilometres (6.8 mi) long and featured two short and sharp climbs, the Colla Micheri and the Capo Mele.